前列环素（PGI2）对大鼠体内垂体前叶激素的影响。

Prostacyclin (PGI2) effects on anterior pituitary hormones in the rat in vivo.

作者信息

Kimball F A, Porteus S E, Kirton K T, Frielink R D, Creasy D M, Dayan A D

出版信息

Prostaglandins. 1979 Sep;18(3):377-85. doi: 10.1016/s0090-6980(79)80056-8.

Abstract

Intravenous injection of 600 microgram PGE2 or PGI2 significantly increased serum LH and prolactin levels in estradiol treated ovariectomized rats. There was no effect on serum FSH concentration. PGE2 and PGI2 stimulated LH release in a non-dose dependent manner, while prolactin levels were positively correlated with the dose administered following PGI2 treatment. 6-keto-PGF1 alpha at a comparable dose had no effect on pituitary hormone levels. Subcutaneous administration of 1 mg/kg or 60 mg/kg PGI2 for seven days significantly depressed serum LH level both in male and female rats. These doses had no effect on serum FSH or prolactin levels.

摘要

静脉注射600微克前列腺素E2（PGE2）或前列环素（PGI2）可显著提高经雌二醇处理的去卵巢大鼠的血清促黄体生成素（LH）和催乳素水平。对血清促卵泡生成素（FSH）浓度无影响。PGE2和PGI2以非剂量依赖性方式刺激LH释放，而PGI2处理后催乳素水平与给药剂量呈正相关。同等剂量的6-酮-前列腺素F1α（6-keto-PGF1α）对垂体激素水平无影响。皮下注射1毫克/千克或60毫克/千克PGI2，连续七天，可显著降低雄性和雌性大鼠的血清LH水平。这些剂量对血清FSH或催乳素水平无影响。