Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Department of Blood Cell Research, Division Research and Landsteiner Laboratory of Amsterdam UMC, Sanquin Blood Supply, Amsterdam, The Netherlands.
Cancer Rep (Hoboken). 2024 Oct;7(10):e70024. doi: 10.1002/cnr2.70024.
Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.
We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.
Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.
These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.
急性髓系白血病（AML）是一种异质性和复杂的血液癌症，需要积极治疗。早期识别和预测治疗后的并发症对于有效疾病管理至关重要。
我们探索了在化疗诱导的中性粒细胞减少症期间 26 例 AML 患者中血浆蛋白水平与发热和感染相关并发症之间的关联。
使用数据依赖的质谱分析进行纵向血浆分析。
基于质谱的血浆分析数据与实验室参数（包括 C 反应蛋白）相关性良好，并揭示了与发热和感染相关并发症相关的更广泛的炎症蛋白网络。
这些数据表明，纵向血浆分析在 AML 患者中具有识别和预测并发症的潜力，可能有助于改善疾病监测和治疗。
