Slabeva Kristina, Baud Maxime O
Zentrum für Experimentelle Neurologie, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Schlaf-Wach Epilepsie Zentrum, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Clocks Sleep. 2024 Oct 21;6(4):589-601. doi: 10.3390/clockssleep6040040.
For centuries, epileptic seizures have been noticed to recur with temporal regularity, suggesting that an underlying biological rhythm may play a crucial role in their timing. In this review, we propose to adopt the framework of chronobiology to study the circadian timing of seizures. We first review observations made on seizure timing in patients with epilepsy and animal models of the disorder. We then present the existing chronobiology paradigm to disentangle intertwined circadian and sleep-wake timing mechanisms. In the light of this framework, we review the existing evidence for specific timing mechanisms in specific epilepsy syndromes and highlight that current knowledge is far from sufficient. We propose that individual seizure chronotypes may result from an interplay between independent timing mechanisms. We conclude with a research agenda to help solve the urgency of ticking seizures.
几个世纪以来，人们注意到癫痫发作会以一定的时间规律反复出现，这表明潜在的生物节律可能在发作时间上起着关键作用。在这篇综述中，我们建议采用生物钟学的框架来研究癫痫发作的昼夜节律时间。我们首先回顾了对癫痫患者和该疾病动物模型的发作时间所做的观察。然后我们介绍现有的生物钟学范式，以厘清相互交织的昼夜节律和睡眠-觉醒时间机制。根据这个框架，我们回顾了特定癫痫综合征中特定时间机制的现有证据，并强调目前的知识还远远不够。我们提出个体发作时型可能是由独立时间机制之间的相互作用导致的。我们最后提出了一个研究议程，以帮助解决癫痫发作定时这一紧迫问题。
