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神经创伤:2024年更新版

Neurotrauma: 2024 update.

作者信息

Priemer David S, Perl Daniel P

机构信息

The Department of Defense/Uniformed Services University Brain Tissue Repository, Bethesda, MD, USA.

Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, USA.

出版信息

Free Neuropathol. 2024 Oct 23;5:26. doi: 10.17879/freeneuropathology-2024-5849. eCollection 2024 Jan.

Abstract

2023 was an important year for research in traumatic brain injury (TBI), particularly as it concerned interests in neuropathology. After reviewing the literature, we present the advancements that we felt were of particular importance to the neuropathology community. Highlighted are articles that report upon: (1) the first large-cohort assessment for the neuropathology of intimate partner violence, (2) the assessment of chronic traumatic encephalopathy (CTE) in young athletes, (3) the observation of cortical sulcal depth vascular changes in CTE, (4) a proposal for a tau immunohistochemical panel to evaluate complex cases of CTE in the context of multiple tauopathies, (5) the relationship of TBI and/or CTE with TDP-43 pathology, (6) repetitive TBI inducing pathology in -transgenic mice, (7) radiologic patterns of head and neck injury following vehicular underbody blast exposure, (8) chronic alterations in brain metal content following repetitive impact TBI, (9) neurovascular unit injury following low-level blast exposure, and finally (10) an assessment of Muhammad Ali's clinical history leading to the conclusion that he suffered from young-onset, idiopathic Parkinson Disease. We close our writing with in memoriam to Dr. Byron A. Kakulas, a renowned figure in the neuropathology of spinal cord injury who we lost in 2023.

摘要

2023年是创伤性脑损伤(TBI)研究的重要一年,尤其是在神经病理学领域。在回顾文献后,我们展示了我们认为对神经病理学领域特别重要的进展。重点介绍的文章包括:(1)首次对亲密伴侣暴力的神经病理学进行的大规模队列评估;(2)对年轻运动员慢性创伤性脑病(CTE)的评估;(3)CTE中皮质沟深度血管变化的观察;(4)关于tau免疫组织化学检测组合的提议,用于在多种tau蛋白病背景下评估复杂的CTE病例;(5)TBI和/或CTE与TDP - 43病理学的关系;(6)重复性TBI在转基因小鼠中诱导的病理学;(7)车辆底部爆炸暴露后头颈部损伤的放射学模式;(8)重复性撞击性TBI后脑金属含量的慢性变化;(9)低水平爆炸暴露后的神经血管单元损伤;最后(10)对穆罕默德·阿里临床病史的评估,得出他患有早发性特发性帕金森病的结论。我们在文末缅怀拜伦·A·卡库拉斯博士,他是脊髓损伤神经病理学领域的知名人物,于2023年离世。

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