Henan Institute of Science and Technology, College of Animal Science and Veterinary Medicine, Xinxiang 453003, China.
Laboratory of Indigenous Cattle Germplasm Innovation, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China.
Cells. 2024 Oct 14;13(20):1699. doi: 10.3390/cells13201699.
Mastitis is a common disease worldwide that affects the development of the dairy industry due to its high incidence and complex etiology. Precise regulation of cell death and survival plays a critical role in maintaining internal homeostasis, organ development, and immune function in organisms, and regulatory abnormalities are a common mechanism of various pathological changes. Recent research has shown that regulated cell death (RCD) plays a crucial role in mastitis. The development of drugs to treat cell death and survival abnormalities that can be widely used in mastitis treatment has important clinical significance. This paper will review the molecular mechanisms of apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis and their regulatory roles in mastitis to provide a new perspective for the targeted treatment of mastitis.
乳腺炎是一种全球性的常见疾病，由于其高发病率和复杂的病因，影响了奶牛养殖业的发展。精确调节细胞死亡和存活对于维持生物体的内部平衡、器官发育和免疫功能至关重要，而调节异常是各种病理变化的常见机制。最近的研究表明，受调控的细胞死亡（RCD）在乳腺炎中起着关键作用。开发可广泛用于乳腺炎治疗的治疗细胞死亡和存活异常的药物具有重要的临床意义。本文将综述细胞凋亡、自噬、细胞焦亡、铁死亡和坏死性凋亡的分子机制及其在乳腺炎中的调控作用，为乳腺炎的靶向治疗提供新视角。
