Chiang De Chen, Yap Beow Keat
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Penang 11800, Malaysia.
Curr Issues Mol Biol. 2024 Sep 25;46(10):10745-10761. doi: 10.3390/cimb46100638.
Aberrant expression of TRIM proteins has been correlated with poor prognosis and metastasis in many cancers, with many TRIM proteins acting as key oncogenic factors. TRIM proteins are actively involved in many cancer signaling pathways, such as p53, Akt, NF-κB, MAPK, TGFβ, JAK/STAT, AMPK and Wnt/β-catenin. Therefore, this review attempts to summarize how three of the most studied TRIMs in recent years (i.e., TRIM25, TRIM28 and TRIM59) are involved directly and indirectly in the crosstalk between the signaling pathways. A brief overview of the key signaling pathways involved and their general cross talking is discussed. In addition, the direct interacting protein partners of these TRIM proteins are also highlighted in this review to give a picture of the potential protein-protein interaction that can be targeted for future discovery and for the development of novel therapeutics against cancer. This includes some examples of protein partners which have been proposed to be master switches to various cancer signaling pathways.
TRIM蛋白的异常表达与许多癌症的不良预后和转移相关，许多TRIM蛋白充当关键致癌因子。TRIM蛋白积极参与许多癌症信号通路，如p53、Akt、NF-κB、MAPK、TGFβ、JAK/STAT、AMPK和Wnt/β-连环蛋白。因此，本综述试图总结近年来研究最多的三种TRIM蛋白（即TRIM25、TRIM28和TRIM59）如何直接和间接参与信号通路之间的串扰。文中讨论了所涉及的关键信号通路及其一般串扰的简要概述。此外，本综述还强调了这些TRIM蛋白的直接相互作用蛋白伙伴，以描绘出潜在的蛋白质-蛋白质相互作用，可为未来的发现以及开发针对癌症的新型疗法提供靶点。这包括一些已被提议作为各种癌症信号通路主开关的蛋白质伙伴实例。
