Kubanek Alicja, Sulima Małgorzata, Szydłowska Aleksandra, Sikorska Katarzyna, Renke Marcin
Division of Occupational, Metabolic and Internal Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland.
Division of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland.
Pathogens. 2024 Sep 30;13(10):851. doi: 10.3390/pathogens13100851.
Malaria is a major international public health problem. The risk of acquiring malaria varies depending on the intensity of transmission and adherence to mosquito precautions and prophylaxis recommendations. Severe malaria can cause significant multiorgan dysfunction, including Intravenous artesunate is the treatment of choice for severe malaria in non-endemic areas. One of the possible events connected with the lifesaving effects of artemisins is post-artesunate haemolysis (PADH), which may be potentially dangerous and under-recognised. We present a case of a seafarer with severe malaria complicated with AKI and PADH, with a good response to steroid treatment. This case highlights the need for malaria prophylaxis in business travellers, e.g., seafarers to malara-endemic regions, and close supervision of patients with malaria even after the completion of antimalarial treatment due to the possibility of late complications.
疟疾是一个重大的国际公共卫生问题。感染疟疾的风险因传播强度以及对蚊虫预防措施和预防建议的遵循情况而异。严重疟疾可导致严重的多器官功能障碍，包括……在非流行地区，静脉注射青蒿琥酯是治疗严重疟疾的首选药物。与青蒿素的救命效果相关的可能事件之一是青蒿琥酯后溶血（PADH），这可能具有潜在危险性且未得到充分认识。我们报告一例患有严重疟疾并伴有急性肾损伤和青蒿琥酯后溶血的海员病例，该病例对类固醇治疗反应良好。该病例凸显了商务旅行者（如前往疟疾流行地区的海员）进行疟疾预防的必要性，以及由于可能出现晚期并发症，即使在完成抗疟治疗后也需对疟疾患者进行密切监测。
