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结直肠穿孔术后由重症监护室专家进行术后管理的预后影响。

Prognostic impact of postoperative management by an intensive care unit intensivist after colonic perforation.

机构信息

Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Clinical Research Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

出版信息

Langenbecks Arch Surg. 2024 Oct 25;409(1):325. doi: 10.1007/s00423-024-03516-4.

Abstract

PURPOSE

Postoperative management for colonic perforation is an important prognostic factor, but whether intensivists perform postoperative management varies between institutions.

METHODS

We investigated 291 patients with colonic perforation between 2018 and 2022. Patients were divided into those managed by an intensivists (ICU group; n = 40) and those not managed by an intensivists (non-ICU group; n = 251). We examined how management by intensivists affected prognosis using inverse probability weighting, and clarified which patients should consult an intensivists.

RESULTS

The ICU group showed a significantly higher shock index (1.15 vs. 0.75, p < 0.01), higher APACHE II score (16.0 vs. 10.0, p < 0.001), and more severe comorbidities (Charlson Comorbidity Index 5.0 vs. 1.0, p < 0.001) and general peritonitis (85% vs. 38%, p < 0.001). Adjusted risk differences were - 24% (-34% to -13%) for 6-month mortality rate. Six-month mortality was improved by ICU intensivist management in patients with general peritonitis (risk difference - 22.8; 95% confidence interval - 34 to -11); APACHE II score ≥20 (-0.79; -1.06 to -0.52); lactate ≥1.6 (-0.38; -0.57 to -0.29); shock index ≥1.0 (-40.01; -54.87 to -25.16); and catecholamine index ≥10 (-41.16; -58.13 to -24.19).

CONCLUSIONS

Intensivists were involved in treating patients in poor general condition, but prognosis was extremely good. Appropriate case consultation with intensivists is important.

摘要

目的

结直肠穿孔的术后管理是一个重要的预后因素,但不同机构的重症监护医生是否进行术后管理存在差异。

方法

我们调查了 2018 年至 2022 年间的 291 例结直肠穿孔患者。患者分为由重症监护医生管理的患者(ICU 组;n=40)和不由重症监护医生管理的患者(非 ICU 组;n=251)。我们使用逆概率加权法研究了重症监护医生的管理如何影响预后,并阐明了哪些患者需要咨询重症监护医生。

结果

ICU 组的休克指数(1.15 比 0.75,p<0.01)、急性生理与慢性健康状况评分 II (APACHE II)评分(16.0 比 10.0,p<0.001)和更严重的合并症(Charlson 合并症指数 5.0 比 1.0,p<0.001)和弥漫性腹膜炎(85%比 38%,p<0.001)均显著更高。调整后的风险差异为 6 个月死亡率降低 24%(-34%至-13%)。在弥漫性腹膜炎(风险差异-22.8;95%置信区间-34 至-11)、APACHE II 评分≥20(-0.79;-1.06 至-0.52)、乳酸≥1.6(-0.38;-0.57 至-0.29)、休克指数≥1.0(-40.01;-54.87 至-25.16)和儿茶酚胺指数≥10(-41.16;-58.13 至-24.19)的患者中,ICU 重症监护医生管理可改善 6 个月死亡率。

结论

重症监护医生参与治疗一般情况较差的患者,但预后极好。与重症监护医生进行适当的病例咨询很重要。

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