Zhang Shujun, Liu Yafeng, Liu Kaijie, Hu Xinjun, Gu Xinyu
Department of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471000, Henan, China.
Henan Medical Key Laboratory of Gastrointestinal Microecology and Hepatology, Luoyang, 471000, China.
Cancer Cell Int. 2024 Oct 25;24(1):347. doi: 10.1186/s12935-024-03528-6.
Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of drug resistance has led to a reduction in the therapeutic effectiveness of targeted drugs, highlighting a crucial need to explore novel therapeutic targets. Many studies have found that epigenetic plays an important role in the occurrence of lung cancer. This review describes the biological function of epigenetic RNA modifications, such as m6A, m5C, m7G, and m1A, and recent advancements in their role in the development, progression, and prognosis of lung cancer. This review aims to provide new guidance for the treatment of lung cancer.
肺癌在全球范围内具有最高的发病率和死亡率，是癌症相关死亡的主要原因。尽管近年来诊断方法和靶向药物迅速发展，但许多肺癌患者并未从有效治疗中获益。耐药性的出现导致靶向药物的治疗效果降低，凸显了探索新型治疗靶点的迫切需求。许多研究发现，表观遗传学在肺癌的发生中起重要作用。本文综述了表观遗传RNA修饰（如m6A、m5C、m7G和m1A）的生物学功能，以及它们在肺癌发生、发展和预后中的作用的最新进展。本文旨在为肺癌治疗提供新的指导。
