Oh Hyeryeon, Lee Jin Sil, Son Panmo, Sim Jooyoung, Park Min Hee, Bang Young Eun, Sung Daekyung, Lim Jong-Min, Choi Won Il
Center for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju 28160, Republic of Korea.
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123, Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea.
Antioxidants (Basel). 2024 Oct 15;13(10):1240. doi: 10.3390/antiox13101240.
Fullerene is a cosmic material with a buckyball-like structure comprising 60 carbon atoms. It has attracted significant interest because of its outstanding antioxidant, antiviral, and antibacterial properties. Natural fullerene (NC60) in shungite meets the demand of biomedical fields to scavenge reactive oxygen species in many diseases. However, its hydrophobicity and poor solubility in water hinder its use as an antioxidant. In this study, highly water-dispersed and stable Pluronic-coated natural fullerene nanoaggregates (NC60/Plu) were prepared from various Pluronic polymers. The water dispersity and stability of NC60 were compared and optimized based on the characteristics of Pluronic polymers including F68, F127, L35, P123, and L81. In particular, NC60 coated with Pluronic F127 at a weight ratio of 1 to 5 showed excellent antioxidant effects both in situ and in vitro. This suggests that the high solubilization of NC60 in Pluronic polymers increases its chance of interacting with reactive oxygen radicals and improves radical scavenging activity. Thus, the optimized NC60/PF127 may be a novel biocompatible antioxidant for treating various diseases associated with oxidative stress.
富勒烯是一种具有类似巴基球结构的宇宙物质，由60个碳原子组成。由于其出色的抗氧化、抗病毒和抗菌特性，它引起了人们的极大兴趣。片岩中的天然富勒烯（NC60）满足了生物医学领域在许多疾病中清除活性氧的需求。然而，其疏水性和在水中的低溶解度阻碍了它作为抗氧化剂的应用。在本研究中，由各种普朗尼克聚合物制备了高度水分散且稳定的普朗尼克包覆天然富勒烯纳米聚集体（NC60/Plu）。基于普朗尼克聚合物（包括F68、F127、L35、P123和L81）的特性，对NC60的水分散性和稳定性进行了比较和优化。特别是，以1:5的重量比用普朗尼克F127包覆的NC60在原位和体外均表现出优异的抗氧化效果。这表明NC60在普朗尼克聚合物中的高溶解性增加了其与活性氧自由基相互作用的机会，并提高了自由基清除活性。因此，优化后的NC60/PF127可能是一种用于治疗各种与氧化应激相关疾病的新型生物相容性抗氧化剂。
