血脑屏障突破的机制及最新研究进展
The Mechanism and Latest Research Progress of Blood-Brain Barrier Breakthrough.
作者信息
Wang Fei, Qi Liujie, Zhang Zhongna, Duan Huimin, Wang Yanchao, Zhang Kun, Li Jingan
机构信息
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
School of Life Science, Zhengzhou University, Zhengzhou 450001, China.
出版信息
Biomedicines. 2024 Oct 10;12(10):2302. doi: 10.3390/biomedicines12102302.
The bloodstream and the central nervous system (CNS) are separated by the blood-brain barrier (BBB), an intricate network of blood vessels. Its main role is to regulate the environment within the brain. The primary obstacle for drugs to enter the CNS is the low permeability of the BBB, presenting a significant hurdle in treating brain disorders. In recent years, significant advancements have been made in researching methods to breach the BBB. However, understanding how to penetrate the BBB is essential for researching drug delivery techniques. Therefore, this article reviews the methods and mechanisms for breaking through the BBB, as well as the current research progress on this mechanism.
血流与中枢神经系统（CNS）被血脑屏障（BBB）分隔开，血脑屏障是一个错综复杂的血管网络。其主要作用是调节脑内环境。药物进入中枢神经系统的主要障碍是血脑屏障的低通透性，这在治疗脑部疾病方面构成了重大障碍。近年来，在研究突破血脑屏障的方法方面取得了重大进展。然而，了解如何穿透血脑屏障对于研究药物递送技术至关重要。因此，本文综述了突破血脑屏障的方法和机制，以及该机制的当前研究进展。
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