Hsieh Yi-Chia, Yao Wei-Jen, Chiu Nan-Tsing, Yang Wen-Horng, Huang Ho-Shiang
Departments of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan.
Departments of Nuclear Medicine, Chia-Yi Christian Hospital, Chiayi 600566, Taiwan.
J Clin Med. 2024 Oct 12;13(20):6090. doi: 10.3390/jcm13206090.
Positron emission tomography (PET) with F-FDG is being used more frequently to evaluate primary pelvic tumors (PTs). However, a standardized hydration protocol is essential for an optimal diuretic effect and constant results. We reviewed 109 patients with PTs who had undergone F-FDG PET/CT examinations between November 2006 and April 2013. Four different protocols were used: (a) no hydration (group 1); (b) oral hydration (800 mL) after an early scan (group 2); (c) intravenous (IV) hydration (500 mL) during an early scan followed by oral hydration (800 mL) and IV furosemide (20 mg) after an early scan (group 3); and (d) oral hydration (800 mL) before an FDG injection followed by the protocol from group 3 (group 4). The maximum standardized uptake (SUV) of the urinary bladder (UB) and PTs and the PT/UB SUV ratios were examined. The UB SUV of group 4 was significantly lower in the early scan compared to that in the other three groups. Group 4 had a significantly higher PT/UB SUV ratio in the early scan than the other three groups, and it also had a 52.5% positivity rate for PTs. The pre-hydration plus forced diuresis protocol yielded the optimal effect of UB radiotracer washout and had the best PT/UB SUV ratio in both scans.
使用F-FDG的正电子发射断层扫描（PET）越来越频繁地用于评估原发性盆腔肿瘤（PT）。然而，标准化的水化方案对于获得最佳利尿效果和稳定结果至关重要。我们回顾了2006年11月至2013年4月期间接受F-FDG PET/CT检查的109例PT患者。使用了四种不同的方案：（a）不水化（第1组）；（b）早期扫描后口服水化（800 mL）（第2组）；（c）早期扫描期间静脉水化（500 mL），随后早期扫描后口服水化（800 mL）并静脉注射速尿（20 mg）（第3组）；以及（d）FDG注射前口服水化（800 mL），随后采用第3组的方案（第4组）。检查了膀胱（UB）和PT的最大标准化摄取值（SUV）以及PT/UB SUV比值。第4组早期扫描时的UB SUV明显低于其他三组。第4组早期扫描时的PT/UB SUV比值明显高于其他三组，其PT阳性率也为52.5%。水化前加用强制利尿方案产生了最佳的UB放射性示踪剂洗脱效果，并且在两次扫描中均具有最佳的PT/UB SUV比值。
