Tai Yihong, Wang Haonan, Dai Yinghong, Yu Liang
Department of Exercise Physiology, School of Sport Science, Beijing Sport University, Beijing, 100084, People's Republic of China.
Xiangya School of Medicine, Central South University, Changsha, 410008, People's Republic of China.
Nat Sci Sleep. 2024 Oct 22;16:1699-1711. doi: 10.2147/NSS.S480491. eCollection 2024.
Sleep disorders and low grip strength often co-occur clinically and are geriatric symptoms that cause significant socioeconomic burden. Previous observational studies have found an association between sleep behaviors and grip strength, but the causal relationship remains unclear.
With the Mendelian randomization (MR) approach, the study aimed to determine the causal association between sleep traits (sleep duration, insomnia, daytime napping, sleep-wake disorders, chronotype) and low grip strength.
The study used genetic variants from the genome-wide association study (GWAS) archived in UK Biobank and FinnGen. We assessed the potential causal relationship between sleep behaviors and grip strength using inverse variance weighting (IVW), weighted median (WM), and MR-Egger. Additionally, we performed sensitivity analyses using Cochran's Q test, MR Egger Intercept test, funnel plots, and leave-one-out method.
We found that sleep duration is causally negatively associated with low grip strength (OR = 0.618, 95% CI = 0.424-0.900, P = 0.012). Sleep-wake disorders have a positive association with low grip strength (OR = 1.018, 95% CI = 1.002-1.034, P = 0.029). Reversely, high low grip strength risk was causally associated with increased daytime napping (OR = 1.018, 95% CI = 1.004-1.032, P = 0.011).
The study revealed causal associations between sleep duration, sleep-wake disorders, and low grip strength. Understanding their relationship helps in early clinical intervention to improve the life quality of the elderly.
睡眠障碍和握力低下在临床上常同时出现，是导致重大社会经济负担的老年症状。既往观察性研究发现睡眠行为与握力之间存在关联，但因果关系仍不明确。
本研究采用孟德尔随机化（MR）方法，旨在确定睡眠特征（睡眠时间、失眠、日间小睡、睡眠-觉醒障碍、昼夜节律类型）与握力低下之间的因果关联。
本研究使用了英国生物银行和芬兰基因库中存档的全基因组关联研究（GWAS）的基因变异。我们使用逆方差加权法（IVW）、加权中位数法（WM）和MR-Egger法评估睡眠行为与握力之间的潜在因果关系。此外，我们使用 Cochr an's Q检验、MR Egger截距检验、漏斗图和留一法进行敏感性分析。
我们发现睡眠时间与握力低下存在因果负相关（OR = 0.618，95%CI = 0.424 - 0.900，P = 0.012）。睡眠-觉醒障碍与握力低下呈正相关（OR = 1.018，95%CI = 1.002 - 1.034，P = 0.029）。相反，握力低下风险高与日间小睡增加存在因果关联（OR = 1.018，95%CI = 1.004 - 1.032，P = 0.011）。
本研究揭示了睡眠时间、睡眠-觉醒障碍与握力低下之间的因果关联。了解它们之间的关系有助于早期临床干预，以提高老年人的生活质量。
