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原住民犬肺泡横纹肌肉瘤病例报告。

A Case Report on Alveolar Rhabdomyosarcoma in an Indigenous Dog.

机构信息

Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.

Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

出版信息

Vet Med Sci. 2024 Nov;10(6):e70100. doi: 10.1002/vms3.70100.

Abstract

A 12 years-old, male indigenous dog was presented to Shahedul Alam Qaderi Teaching Veterinary Hospital (SAQTVH) in Chattogram, Bangladesh with a large tumour on its right front leg. The histopathological findings of the tumour were highly suggestive of an alveolar rhabdomyosarcoma (ARMS). The tumour was surgically removed from the dog. While there had been no recurrence for 5 months, the patient died 5 months post-operatively. The cause of the death and presence of metastasis could not be confirmed as follow-up investigations were declined by the owner. A histopathological study showed poorly differentiated neoplastic mononuclear cells forming nests in an alveolar pattern. Despite that the limited resources prevented myogenin staining for diagnostic confirmation, the well-contained, defined appearance of the tumour supports the diagnosis of ARMS. This report highlights the challenges in diagnosing and treating ARMS in indigenous dogs and emphasizes the need for further research and diagnostic markers to improve detection and management.

摘要

一只 12 岁的雄性土狗被带到孟加拉国吉大港的沙胡尔·阿拉姆·卡迪里教学兽医医院(SAQTVH),其右前腿上有一个大肿瘤。肿瘤的组织病理学发现高度提示为肺泡横纹肌肉瘤(ARMS)。肿瘤已从狗身上切除。虽然 5 个月内没有复发,但术后 5 个月患者死亡。由于主人拒绝进行随访调查,因此无法确定死亡原因和是否存在转移。组织病理学研究显示,分化不良的肿瘤单核细胞以肺泡模式形成巢。尽管有限的资源阻止了肌球蛋白染色以进行诊断确认,但肿瘤的良好包含、明确的外观支持 ARMS 的诊断。本报告强调了在土狗中诊断和治疗 ARMS 所面临的挑战,并强调需要进一步的研究和诊断标志物来提高检测和管理水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4787/11519992/202978a6975e/VMS3-10-e70100-g003.jpg

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