Shen Henry Goh Di, Zhang Yue, Leow Wei Qiang
Duke-NUS Medical School, Singapore.
Department of Anatomical Pathology, Singapore General Hospital, Singapore.
J Pathol Transl Med. 2025 Mar;59(2):133-138. doi: 10.4132/jptm.2024.09.27. Epub 2024 Oct 31.
Hepatic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) represents a rare form of liver malignancy. The absence of distinct clinical and radiological characteristics, compounded by its rare occurrence, contributes to a challenging diagnosis. Here, we report a case of a 54-year-old Chinese female with a background of chronic hepatitis B virus treated with entecavir and complicated by advanced fibrosis presenting with a liver mass found on her annual surveillance ultrasound. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor were consistent with EBV+ IFDCS with distinct non-caseating granulomatous inflammation. Our case illustrates the importance of considering EBV+ IFDCS in the differential diagnosis of hepatic inflammatory lesions. Awareness of this entity and its characteristic features is essential for accurately diagnosing and managing this rare neoplasm.
肝Epstein-Barr病毒阳性炎性滤泡树突状细胞肉瘤（EBV+ IFDCS）是一种罕见的肝脏恶性肿瘤形式。由于缺乏明显的临床和影像学特征，再加上其罕见性，导致诊断具有挑战性。在此，我们报告一例54岁的中国女性病例，该患者有慢性乙型肝炎病毒感染史，接受恩替卡韦治疗，并发晚期纤维化，在年度超声监测中发现肝脏肿块。临床怀疑为肝细胞癌而行肝切除术。肿瘤的免疫形态学特征与EBV+ IFDCS一致，并伴有明显的非干酪样肉芽肿性炎症。我们的病例说明了在肝脏炎性病变的鉴别诊断中考虑EBV+ IFDCS的重要性。认识到这一实体及其特征对于准确诊断和管理这种罕见肿瘤至关重要。
