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亚急性脑膜炎:布鲁氏菌病的一种罕见表现。

Subacute Meningitis: A Rare Presentation of Brucellosis.

作者信息

Duarte Mafalda, Tiago Vasco, Sousa Raquel, Aldomiro Fernando

机构信息

Internal Medicine, Hospital Prof. Doutor Fernando Fonseca, Amadora, PRT.

Internal Medicine, Hospital Dr. José de Almeida, Cascais, PRT.

出版信息

Cureus. 2024 Sep 29;16(9):e70445. doi: 10.7759/cureus.70445. eCollection 2024 Sep.

Abstract

A young male adult presented with a two-week-long history of myoarthralgia, vomiting, febrile sensation, holocranial headache with photophobia, neck stiffness, anorexia, and weight loss. He worked as a butcher in a local slaughterhouse, and two of his coworkers had recently been diagnosed with brucellosis. On his fourth visit to the Emergency Department (ED), fever was observed for the first time. He was admitted for subacute meningitis. A lumbar puncture revealed high protein concentration, low glucose concentration, and pleocytosis without predominance. He was started on empirical treatment for acute meningitis and neurobrucellosis with ceftriaxone, doxycycline, and rifampin. There was a complete symptom remission over one week. The etiological investigation yielded a positive cerebrospinal fluid (CSF) and serum Rose Bengal Tests (RBTs), as well as a positive anti- IgG titer, leading to a final diagnosis of neurobrucellosis. After nine months of antimicrobial therapy and two years of follow-up, the patient remained asymptomatic.

摘要

一名年轻男性成年人出现了为期两周的肌关节痛、呕吐、发热感、伴有畏光的全颅头痛、颈部僵硬、厌食和体重减轻症状。他在当地一家屠宰场担任屠夫,他的两名同事最近被诊断出患有布鲁氏菌病。在他第四次前往急诊科就诊时,首次观察到发热症状。他因亚急性脑膜炎入院。腰椎穿刺显示蛋白浓度高、葡萄糖浓度低且有细胞增多但无优势。他开始接受用头孢曲松、多西环素和利福平进行的急性脑膜炎和神经型布鲁氏菌病的经验性治疗。一周内症状完全缓解。病因学调查显示脑脊液(CSF)和血清玫瑰红试验(RBTs)呈阳性,以及抗IgG滴度呈阳性,最终诊断为神经型布鲁氏菌病。经过九个月的抗菌治疗和两年的随访,患者仍无症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad71/11521439/d75213786c10/cureus-0016-00000070445-i01.jpg

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