Bikdeli Arezou, Li Daqing, Malide Minati, Nouri Meysam, Sun Hongsheng, Yang Qingrui, Golsanami Naser, Liu Dongxia
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.
School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.
Biomed Res Int. 2023 Jan 27;2023:3668689. doi: 10.1155/2023/3668689. eCollection 2023.
Pregnancy in systemic lupus erythematosus (SLE) patients is a challenge due to the potential maternal and fetal complications. Therefore, a multidisciplinary assessment of disease risk before and during pregnancy is essential to improve pregnancy outcomes.
Our purpose was to (i) define clusters of patients with similar history and laboratory features and determine the associative maternal and perinatal outcomes and (ii) evaluate the risk spectrum of maternal and perinatal outcomes of pregnancy in SLE patients, represented by our established risk-assessment chart.
Medical records of 119 patients in China were analyzed retrospectively. Significant variables with < 0.05 were selected. The self-organizing map was used for clustering the data based on historical background and laboratory features.
Clustering was conducted using 21 maternal and perinatal features. Five clusters were recognized, and their prominent maternal manifestations were as follows: cluster 1 (including 27.73% of all patients): preeclampsia and lupus nephritis; cluster 2 (22.69%): oligohydramnios, uterus scar, and femoral head necrosis; cluster 3 (13.45%): upper respiratory tract infection; cluster 4 (15.97%): premature membrane rupture; and cluster 5 (20.17%): no problem.
Pregnancy outcomes in SLE women fell into three categories, namely high risk, moderate risk, and low risk. Present manifestations, besides the medical records, are a potential assessment means for better management of pregnant SLE patients.
系统性红斑狼疮（SLE）患者怀孕具有挑战性，因为存在潜在的母婴并发症。因此，孕期前后对疾病风险进行多学科评估对于改善妊娠结局至关重要。
我们的目的是（i）定义具有相似病史和实验室特征的患者群，并确定相关的孕产妇和围产期结局；（ii）以我们建立的风险评估图表为代表，评估SLE患者妊娠的孕产妇和围产期结局的风险谱。
回顾性分析中国119例患者的病历。选择P<0.05的显著变量。自组织映射用于根据历史背景和实验室特征对数据进行聚类。
使用21项孕产妇和围产期特征进行聚类。识别出五个聚类，其突出的孕产妇表现如下：聚类1（占所有患者的27.73%）：先兆子痫和狼疮性肾炎；聚类2（22.69%）：羊水过少、子宫瘢痕和股骨头坏死；聚类3（13.45%）：上呼吸道感染；聚类4（15.97%）：胎膜早破；聚类5（20.17%）：无问题。
SLE女性的妊娠结局分为高风险、中风险和低风险三类。除病历外，当前表现是更好管理SLE孕妇的潜在评估手段。
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