Watanabe Naoki, Harada Sakiko, Sato Shoko, Fukuda Yasutaka, Tanaka Yuina, Yanashima Kensuke, Sato Eriko, Taniguchi Daisuke, Tomizawa Yuji, Hattori Nobutaka, Ando Miki
Department of Hematology, Juntendo University Nerima Hospital, Tokyo, Japan.
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Case Rep Oncol. 2024 Oct 22;17(1):1201-1207. doi: 10.1159/000541552. eCollection 2024 Jan-Dec.
Neurolymphomatosis (NL) is a rare condition characterized by the infiltration of malignant lymphoma cells into the peripheral nervous system. The optimal treatment for NL remains unclear, and patients with secondary NL have a poor prognosis. Although early recognition of NL may contribute to successful treatment, the predictive factors for secondary NL are yet to be established.
Here, we present our investigation on the predictive factors for secondary NL, and report two cases of secondary NL with a literature review. We analyzed chromosomal abnormalities in patients with secondary NL and found a common deletion of chromosome 10 and add(11)(p11). The chromosomal abnormalities might be a predictive factor for secondary NL; therefore, confirmation of chromosomal abnormalities can possibly give a hint for early detect of secondary NL. Prompt histopathological examination or imaging techniques can lead to early diagnosis of secondary NL in patients with diffuse large B-cell lymphoma (DLBCL).
When neurological symptoms manifest in patients with DLBCL and there are chromosomal abnormalities, the possible development of secondary NL should be considered.
神经淋巴瘤（NL）是一种罕见疾病，其特征为恶性淋巴瘤细胞浸润至周围神经系统。NL的最佳治疗方法仍不明确，继发性NL患者预后较差。尽管早期识别NL可能有助于成功治疗，但继发性NL的预测因素尚未确立。
在此，我们展示了对继发性NL预测因素的研究，并报告2例继发性NL病例并进行文献复习。我们分析了继发性NL患者的染色体异常情况，发现10号染色体常见缺失及11号染色体（p11）增加。这些染色体异常可能是继发性NL的预测因素；因此，确认染色体异常可能为早期检测继发性NL提供线索。及时的组织病理学检查或影像学技术可导致弥漫性大B细胞淋巴瘤（DLBCL）患者继发性NL的早期诊断。
当DLBCL患者出现神经症状且存在染色体异常时，应考虑继发性NL的可能发展。
