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饮酒会对衰老大脑中的前额叶皮层神经元内在兴奋性和自发性神经递质信号产生持久影响。

Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice.

机构信息

Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.

Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.

出版信息

Neurobiol Aging. 2025 Jan;145:42-54. doi: 10.1016/j.neurobiolaging.2024.09.014. Epub 2024 Oct 15.

Abstract

Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of alcohol use on excitation and inhibition on the aging brain is unclear. We examined the effect of moderate voluntary binge alcohol consumption on the aged, pre-disease neuronal environment by measuring intrinsic excitability and spontaneous neurotransmission on prefrontal cortical pyramidal (excitatory, glutamatergic) and non-pyramidal (inhibitory, GABAergic) neurons following a prolonged period of abstinence from alcohol in mice. Results highlight that binge alcohol consumption has lasting impacts on the electrophysiological properties of prefrontal cortical neurons. A profound increase in excitatory events onto layer 2/3 non-pyramidal neurons following alcohol consumption was seen, along with altered intrinsic excitability of pyramidal neurons, which could have a range of effects on cognitive disorder progression, such as Alzheimer's Disease, in humans. These results indicate that moderate voluntary alcohol influences the pre-disease environment in aging and highlight the need for further mechanistic investigation into this risk factor.

摘要

酒精使用障碍(AUD)和认知能力下降都包括皮质兴奋和抑制平衡的破坏,但酒精使用对衰老大脑兴奋和抑制的潜在作用尚不清楚。我们通过测量长期戒酒的老龄、无疾病的小鼠前额皮质锥体(兴奋性谷氨酸能)和非锥体(抑制性 GABA 能)神经元的内在兴奋性和自发性神经传递,来检测中度自愿 binge 饮酒对衰老大脑神经元环境的影响。结果表明, binge 饮酒对前额皮质神经元的电生理特性有持久的影响。饮酒后,第 2/3 层非锥体神经元的兴奋性事件明显增加,同时锥体神经元的内在兴奋性发生改变,这可能对人类的认知障碍进展(如阿尔茨海默病)产生一系列影响。这些结果表明,中度自愿饮酒会影响衰老过程中的疾病前环境,并强调需要进一步深入研究这一风险因素的机制。

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