Nielsen Maria B, Benn Marianne, Nordestgaard Børge G, Skov Lone, Çolak Yunus
Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Clin Chem. 2025 Feb 3;71(2):286-295. doi: 10.1093/clinchem/hvae160.
Psoriasis is a chronic inflammatory skin disorder often associated with obesity. Adiponectin, an anti-inflammatory protein-hormone secreted by adipose tissue, may be a link between obesity and psoriasis. We hypothesized that low plasma adiponectin is associated with an increased risk of psoriasis in observational and causal genetic studies.
In observational analyses, we used information on plasma adiponectin and psoriasis in 30 045 individuals from the Copenhagen General Population Study (CGPS). In one-sample Mendelian randomization analyses, we used genetic information on adiponectin and psoriasis in 107 308 individuals from the CGPS. In two-sample Mendelian randomization analyses, we used genetic information on adiponectin from the ADIPOGen consortium and genetic information on psoriasis in 373 338 and 462 933 individuals from the FinnGen study and UK Biobank (UKB).
In observational analyses, a 1-unit log-transformed higher plasma adiponectin was associated with a hazard ratio (HR) for psoriasis of 0.67 (95% confidence interval: 0.48-0.94) in an age- and sex-adjusted model but not in a multivariable adjusted model including obesity measures with a HR of 0.95 (0.66-1.35). In genetic one-sample Mendelian randomization analysis, a 1-unit log-transformed higher plasma adiponectin was not associated with a causal risk ratio for psoriasis of 1.33 (0.77-2.32) in the CGPS. In two-sample Mendelian randomization analyses, a 1-unit log-transformed higher plasma adiponectin was not associated with causal risk ratios for psoriasis of 0.96 (0.81-1.14) in FinnGen and 1.00 (1.00-1.01) in UKB.
Low plasma adiponectin is associated with increased risk of psoriasis in age- and sex-adjusted observational analyses; however, this was not the case after adjustment for obesity measures or in causal genetic analyses.
银屑病是一种慢性炎症性皮肤病，常与肥胖相关。脂联素是一种由脂肪组织分泌的抗炎蛋白激素，可能是肥胖与银屑病之间的联系。我们假设在观察性研究和因果基因研究中，血浆脂联素水平低与银屑病风险增加有关。
在观察性分析中，我们使用了哥本哈根普通人群研究（CGPS）中30045名个体的血浆脂联素和银屑病信息。在单样本孟德尔随机化分析中，我们使用了CGPS中107308名个体的脂联素和银屑病基因信息。在两样本孟德尔随机化分析中，我们使用了ADIPOGen联盟的脂联素基因信息以及芬兰基因研究和英国生物银行（UKB）中373338名和462933名个体的银屑病基因信息。
在观察性分析中，在年龄和性别调整模型中，血浆脂联素对数转换后每升高1个单位，银屑病的风险比（HR）为0.67（95%置信区间：0.48 - 0.
