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孟德尔随机化分析探讨组织蛋白酶与双相情感障碍的关系。

Mendelian randomisation analysis to explore the association between cathepsins and bipolar disorder.

机构信息

Key Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, 110122, Liaoning, China.

Research Institute for "Ren" Doctors, School of Medical Humanities, China Medical University, Shenyang, 110122, Liaoning, China.

出版信息

BMC Psychiatry. 2024 Oct 31;24(1):758. doi: 10.1186/s12888-024-06210-3.

DOI:10.1186/s12888-024-06210-3
PMID:39482620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11529291/
Abstract

INTRODUCTION

Bipolar disorder is a psychiatric condition characterized by the coexistence of depression and mania. Diagnosis of this disorder can be challenging due to limited pathologic and experimental tools. Treatment compliance is often poor due to medication side effects. Although cathepsin is known to play a significant role in diseases such as tumors and osteoporosis, its role in psychiatric disorders is not yet fully understood.

OBJECTIVE

The aim of this study was to investigate the relationship between cathepsin in the blood circulation and bipolar disorder.

METHODS

The causal relationship between cathepsin and different subtypes of bipolar affective disorder was explored using bidirectional Mendelian randomization analysis and multivariate analysis.

RESULTS

It was found that cathepsin H level was a protective factor for type II bipolar disorder. No potential causal relationship was found between cathepsin H and type I bipolar disorder, but cathepsin B changes with the development of type I bipolar disorder. A causal relationship was found between cathepsin H and cerebral dopamine neurotrophic factor.

CONCLUSIONS

In conclusion, cathepsin H may be a diagnostic target for bipolar II disorder and may play a guiding role in clinical diagnosis. Cathepsin H may have an effect on BD through cerebral dopamine neurotrophic factor.

摘要

简介

双相情感障碍是一种精神疾病，其特征是抑郁和躁狂同时存在。由于病理和实验工具有限，这种疾病的诊断具有挑战性。由于药物的副作用，治疗依从性往往很差。尽管组织蛋白酶已知在肿瘤和骨质疏松症等疾病中发挥重要作用，但它在精神疾病中的作用尚未完全阐明。

目的

本研究旨在探讨血液循环中的组织蛋白酶与双相情感障碍之间的关系。

方法

采用双向孟德尔随机化分析和多变量分析探讨组织蛋白酶与不同亚型双相情感障碍之间的因果关系。

结果

发现组织蛋白酶 H 水平是 II 型双相情感障碍的保护因素。未发现组织蛋白酶 H 与 I 型双相情感障碍之间存在潜在的因果关系，但组织蛋白酶 B 随 I 型双相情感障碍的发展而变化。组织蛋白酶 H 与脑多巴胺神经营养因子之间存在因果关系。

结论

总之，组织蛋白酶 H 可能是双相 II 型障碍的诊断靶点，并可能对临床诊断具有指导作用。组织蛋白酶 H 可能通过脑多巴胺神经营养因子对 BD 产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/5b51798ec570/12888_2024_6210_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/179b4af4b47d/12888_2024_6210_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/861ff8e07de9/12888_2024_6210_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/7ca993d6ab3b/12888_2024_6210_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/5b51798ec570/12888_2024_6210_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/179b4af4b47d/12888_2024_6210_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/861ff8e07de9/12888_2024_6210_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/7ca993d6ab3b/12888_2024_6210_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8d/11529291/5b51798ec570/12888_2024_6210_Fig4_HTML.jpg

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