Karima Saeed, Khatami Seyyed Hossein, Ehtiati Sajad, Khoshtinatnikkhouy Sara, Kachouei Reza Ataei, Jahan-Abad Ali Jahanbazi, Tafakhori Abbas, Firoozpour Hadis, Salmani Farzaneh
Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Inflammation. 2024 Nov 2. doi: 10.1007/s10753-024-02176-2.
Acetyl-11-keto-β-boswellic acid is one of the main active components of Boswellia sp. resin with the most potent anti-inflammatory activity. In recent years, herbal therapy has received considerable attention for the treatments of inflammatory and demyelinating diseases such as Multiple sclerosis (MS). Studies have shown that herbal compounds could enhance myelin repair and suppress inflammation. This study was designed to investigate the therapeutic effects of intraperitoneal administration of AKBA in Experimental Autoimmune Encephalomyelitis (EAE), as an animal model of MS. Following EAE induction in female C57BL/6J mice, animals were treated with AKBA and the levels of different serum inflammatory mediators, as well as motor functions, myelination, and inflammatory cell infiltration were assessed. Our results revealed that the application of AKBA alleviated EAE clinical severity, and suppressed inflammation, demyelination, leukocyte infiltration, and gliosis in EAE mice. Our findings suggest that the therapeutic effects of AKBA are likely a consequence of its neuroprotective and anti-inflammatory properties. The beneficial effects of AKBA may therefore provide new insights in various neuroinflammatory diseases such as MS and thereby could serve as a potential treatment candidate.
乙酰-11-酮基-β-乳香酸是乳香属树脂中具有最强抗炎活性的主要活性成分之一。近年来，草药疗法在治疗诸如多发性硬化症（MS）等炎症性和脱髓鞘疾病方面受到了广泛关注。研究表明，草药化合物可以促进髓鞘修复并抑制炎症。本研究旨在探讨腹腔注射乙酰-11-酮基-β-乳香酸（AKBA）对实验性自身免疫性脑脊髓炎（EAE）（一种MS动物模型）的治疗效果。在雌性C57BL/6J小鼠中诱导EAE后，用AKBA对动物进行治疗，并评估不同血清炎症介质水平、运动功能、髓鞘形成以及炎症细胞浸润情况。我们的结果显示，应用AKBA可减轻EAE的临床严重程度，并抑制EAE小鼠的炎症、脱髓鞘、白细胞浸润和胶质细胞增生。我们的研究结果表明，AKBA的治疗效果可能是其神经保护和抗炎特性的结果。因此，AKBA的有益作用可能为诸如MS等各种神经炎症性疾病提供新的见解，从而可能成为一种潜在的治疗候选药物。
