Brooke Grant, Wendel Sebastian, Banerjee Abhineet, Wallace Nicholas
Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
Department of Kinesiology, Kansas State University, Manhattan, KS 66506, USA.
Tumour Virus Res. 2024 Dec;18:200292. doi: 10.1016/j.tvr.2024.200292. Epub 2024 Oct 25.
Cervical cancer (CaCx) is a major public health issue, with over 600,000 women diagnosed annually. CaCx kills someone every 90 s, mostly in low- and middle-income countries. There are effective yet imperfect mechanisms to prevent CaCx. Since human papillomavirus (HPV) infections cause most CaCx, they can be prevented by vaccination. Screening methodologies can identify premalignant lesions and allow interventions before a CaCx develops. However, these tools are less feasible in resource-poor environments. Additionally, current screening modalities cannot triage lesions based on their relative risk of progression, which results in overtreatment. CaCx care relies heavily on genotoxic agents that cause severe side effects. This review discusses ways that recent technological advancements could be leveraged to improve CaCx care and prevention.
宫颈癌是一个重大的公共卫生问题，每年有超过60万女性被诊断出患有此病。宫颈癌每90秒就会夺走一人的生命，其中大多数发生在低收入和中等收入国家。目前有有效的但并不完善的宫颈癌预防机制。由于人乳头瘤病毒（HPV）感染是导致大多数宫颈癌的原因，因此可以通过接种疫苗来预防。筛查方法可以识别癌前病变，并在宫颈癌发生之前进行干预。然而，这些工具在资源匮乏的环境中不太可行。此外，目前的筛查方式无法根据病变进展的相对风险对病变进行分类，这导致了过度治疗。宫颈癌的治疗严重依赖会引起严重副作用的基因毒性药物。本综述讨论了如何利用近期的技术进步来改善宫颈癌的治疗和预防。
