Department of Pediatric Gastroenterology and Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
World J Gastroenterol. 2024 Oct 21;30(39):4329-4332. doi: 10.3748/wjg.v30.i39.4329.
Considering the bidirectional crosstalk along the gut-liver axis, gut-derived microorganisms and metabolites can be released into the liver, potentially leading to liver injury. In this editorial, we comment on several studies published in the recent issue of the . We focus specifically on the roles of gut microbiota in selected gastrointestinal (GI) diseases that are prevalent, such as inflammatory bowel disease, metabolic dysfunction-associated steatotic liver disease, and hepatitis B virus-related portal hypertension. Over the past few decades, findings from both preclinical and clinical studies have indicated an association between compositional and metabolic changes in the gut microbiota and the pathogenesis of the aforementioned GI disorders. However, studies elucidating the mechanisms underlying the host-microbiota interactions remain limited. The purpose of this editorial is to summarize current findings and provide insights regarding the context-specific roles of gut microbiota. Ultimately, the discovery of microbiome-based biomarkers may facilitate disease diagnosis and the development of personalized medicine.
考虑到肠-肝轴的双向串扰，肠道来源的微生物和代谢物可以释放到肝脏，可能导致肝损伤。在这篇社论中，我们对近期发表在《胃肠病学》杂志上的几项研究进行了评论。我们特别关注肠道微生物群在几种常见胃肠道（GI）疾病中的作用，如炎症性肠病、代谢功能障碍相关脂肪性肝病和乙型肝炎病毒相关门静脉高压症。在过去几十年中，临床前和临床研究的结果表明，肠道微生物群的组成和代谢变化与上述 GI 疾病的发病机制有关。然而，阐明宿主-微生物群相互作用机制的研究仍然有限。本社论的目的是总结目前的发现，并提供关于肠道微生物群具体作用的见解。最终，基于微生物组的生物标志物的发现可能有助于疾病诊断和个性化医疗的发展。
