The outbreak of COVID-19 swept massive masses causing rhinocerebral mucormycosis, a fatal mycotic infection, and high mortality among humans. ​It affects individuals with weakened immune systems, resulting in severe ulcers on the palate or perforation of the palate, accompanied by blackish necrotic tissue and exposure of underlying bone.​ Some of the key symptoms include rhinorrhea, facial swelling, pain in the orofacial region, varying degrees of fever, headaches, blurred vision due to proptosis, and involvement of the contents of the orbit. The impairment is enormous and thus needs a surgical resection of the palate and associated structures, leaving the patient with both compromised function and psychological impairment. This case report presents a new digital technique for the rehabilitation of acquired maxillary defects with patient-specific implants.