Allam Amal Farahat, Farag Hoda Fahmy, Shehab Amel Youssef, El Sahy Ahmed Soliman, Khalil Safia Saleh, El-Latif Naglaa Fathi Abd
Department of Parasitology, Medical Research Institute, University of Alexandria, 165 El Horreya avenue, El Hadara, Alexandria, Egypt.
J Parasit Dis. 2024 Dec;48(4):936-943. doi: 10.1007/s12639-024-01721-y. Epub 2024 Aug 21.
The implication of human () infection in concomitance with other risk factors such as hepatitis C virus (HCV) and hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC) is still under controversy. This work aimed. to evaluate the role of infection in association with hepatitis B virus (HBV), hepatitis C virus (HCV) and other risk factors in the development and/or progress of HCC.
The present study was carried out on 90 HCC patients recruited from Kafr El-Sheikh Liver Disease Research Institute. After obtaining their informed consents, socio-demographic and clinical data were collected and patients were examined for by Kato-Katz and indirect hemagglutination (IHA) techniques. Alpha-fetoprotein (AFP) level was determined. The Child-Pugh scoring system and Barcelona Clinic Liver Cancer (BCLC) staging system were used to evaluate the pathological features of the studied patients.
All participants were negative for active by Kato-Katz. Based on IHA, the participants were categorized into two groups: group I: sixty-two patients negative for and group II: twenty-eight schistosomiasis positive. The patients' age ranged between 40->60, HCC was more prevalent in the age range of > 50-60 years in both groups. Males were more than females and rural participants were more than urban patients in both groups. Most of the patients (88.9%) had HCV while 7.8% had HBV. A higher proportion of HCC patients showed concomitant HCV and (92.6%) than the negative group. The frequency of upper gastrointestinal bleeding (GIB) was four-fold higher among HCC patients positive for schistosomiasis compared to negative schistosomiasis cases (64% vs. 16%). Alpha-fetoprotein (AFP) level was higher in group II than that in group I with no significant difference. Statistical analysis showed no difference between the two studied groups regarding Child scores. On the contrary, BCLC class D was significantly higher among HCC positive schistosomiasis cases compared to the negative group.
Concomitant with HCV and HBV potentiate HCC progression.
人类（）感染与丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）等其他危险因素同时存在时在肝细胞癌（HCC）发生发展中的影响仍存在争议。本研究旨在评估（）感染与乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）及其他危险因素在肝细胞癌发生和/或进展中的作用。
本研究对从卡夫尔谢赫肝病研究所招募的90例肝细胞癌患者进行。在获得他们的知情同意后，收集社会人口统计学和临床数据，并采用加藤厚涂片法和间接血凝试验（IHA）技术对患者进行（）检测。测定甲胎蛋白（AFP）水平。采用Child-Pugh评分系统和巴塞罗那临床肝癌（BCLC）分期系统评估研究患者的病理特征。
加藤厚涂片法检测显示所有参与者的（）均为阴性。基于IHA，参与者被分为两组：第一组：62例（）阴性患者；第二组：28例血吸虫病阳性患者。患者年龄在40->60岁之间，两组中HCC在>50-60岁年龄组更为常见。两组中男性均多于女性，农村参与者多于城市患者。大多数患者（88.9%）感染HCV，7.8%感染HBV。与（）阴性组相比，HCC患者中同时感染HCV和（）的比例更高（92.6%）。血吸虫病阳性的HCC患者上消化道出血（GIB）的发生率是血吸虫病阴性病例的四倍（64%对16%）。第二组的甲胎蛋白（AFP）水平高于第一组，但差异无统计学意义。统计分析显示，两组在Child评分方面无差异。相反，血吸虫病阳性的HCC病例中BCLC D期显著高于阴性组。
（）与HCV和HBV同时存在会促进HCC进展。
