感染与肝细胞癌：一项共病研究
infection and hepatocellular carcinoma: a comorbidity study.
作者信息
Allam Amal Farahat, Farag Hoda Fahmy, Shehab Amel Youssef, El Sahy Ahmed Soliman, Khalil Safia Saleh, El-Latif Naglaa Fathi Abd
机构信息
Department of Parasitology, Medical Research Institute, University of Alexandria, 165 El Horreya avenue, El Hadara, Alexandria, Egypt.
出版信息
J Parasit Dis. 2024 Dec;48(4):936-943. doi: 10.1007/s12639-024-01721-y. Epub 2024 Aug 21.
BACKGROUND
The implication of human () infection in concomitance with other risk factors such as hepatitis C virus (HCV) and hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC) is still under controversy. This work aimed. to evaluate the role of infection in association with hepatitis B virus (HBV), hepatitis C virus (HCV) and other risk factors in the development and/or progress of HCC.
METHODS
The present study was carried out on 90 HCC patients recruited from Kafr El-Sheikh Liver Disease Research Institute. After obtaining their informed consents, socio-demographic and clinical data were collected and patients were examined for by Kato-Katz and indirect hemagglutination (IHA) techniques. Alpha-fetoprotein (AFP) level was determined. The Child-Pugh scoring system and Barcelona Clinic Liver Cancer (BCLC) staging system were used to evaluate the pathological features of the studied patients.
RESULTS
All participants were negative for active by Kato-Katz. Based on IHA, the participants were categorized into two groups: group I: sixty-two patients negative for and group II: twenty-eight schistosomiasis positive. The patients' age ranged between 40->60, HCC was more prevalent in the age range of > 50-60 years in both groups. Males were more than females and rural participants were more than urban patients in both groups. Most of the patients (88.9%) had HCV while 7.8% had HBV. A higher proportion of HCC patients showed concomitant HCV and (92.6%) than the negative group. The frequency of upper gastrointestinal bleeding (GIB) was four-fold higher among HCC patients positive for schistosomiasis compared to negative schistosomiasis cases (64% vs. 16%). Alpha-fetoprotein (AFP) level was higher in group II than that in group I with no significant difference. Statistical analysis showed no difference between the two studied groups regarding Child scores. On the contrary, BCLC class D was significantly higher among HCC positive schistosomiasis cases compared to the negative group.
CONCLUSION
Concomitant with HCV and HBV potentiate HCC progression.
背景
人类（）感染与丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）等其他危险因素同时存在时在肝细胞癌（HCC）发生发展中的影响仍存在争议。本研究旨在评估（）感染与乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）及其他危险因素在肝细胞癌发生和/或进展中的作用。
方法
本研究对从卡夫尔谢赫肝病研究所招募的90例肝细胞癌患者进行。在获得他们的知情同意后，收集社会人口统计学和临床数据，并采用加藤厚涂片法和间接血凝试验（IHA）技术对患者进行（）检测。测定甲胎蛋白（AFP）水平。采用Child-Pugh评分系统和巴塞罗那临床肝癌（BCLC）分期系统评估研究患者的病理特征。
结果
加藤厚涂片法检测显示所有参与者的（）均为阴性。基于IHA，参与者被分为两组：第一组：62例（）阴性患者；第二组：28例血吸虫病阳性患者。患者年龄在40->60岁之间，两组中HCC在>50-60岁年龄组更为常见。两组中男性均多于女性，农村参与者多于城市患者。大多数患者（88.9%）感染HCV，7.8%感染HBV。与（）阴性组相比，HCC患者中同时感染HCV和（）的比例更高（92.6%）。血吸虫病阳性的HCC患者上消化道出血（GIB）的发生率是血吸虫病阴性病例的四倍（64%对16%）。第二组的甲胎蛋白（AFP）水平高于第一组，但差异无统计学意义。统计分析显示，两组在Child评分方面无差异。相反，血吸虫病阳性的HCC病例中BCLC D期显著高于阴性组。
结论
（）与HCV和HBV同时存在会促进HCC进展。
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