在帕金森病治疗的脑深部电刺激手术中降低血管并发症发生率:一项单中心600例患者的病例系列研究

Minimising the rate of vascular complications in Deep Brain Stimulation surgery for the management of Parkinson's disease: a single-centre 600-patient case series.

作者信息

Cook Raymond, Chennell Dutton Nyssa, Silburn Peter A, Meagher Linton J, Fracchia George, Anderson Nathan, Cooper Glen, Dinh Hoang-Mai, Cook Stuart J, Silberstein Paul

机构信息

Neurosurgery, North Shore Private Hospital, Sydney, NSW, Australia.

Neurosurgery, Royal North Shore Hospital, Sydney, New South Wales, Australia.

出版信息

BMJ Neurol Open. 2024 Oct 26;6(2):e000793. doi: 10.1136/bmjno-2024-000793. eCollection 2024.

Abstract

OBJECTIVES

Deep Brain Stimulation (DBS) is an effective, yet underused therapy for people living with Parkinson's disease (PD) in whom tremor, motor fluctuations and/or dyskinesia are not satisfactorily controlled by oral medical therapy. Fear of vascular complications related to the operative procedure remains a strong reason for both the referrer and patient reluctance. We review the incidence of vascular complications in the first 600 patients with Parkinson's disease treated at our centre by a single neurologist/neurosurgical team.

METHODS

Surgical data routinely collected for patients who underwent DBS implantation for the management of PD between the years 2001-2023 was retrospectively reviewed. Incidences of vascular complication were analysed in detail, examining causal factors.

RESULTS

Including reimplantations, 600 consecutive DBS patients underwent implantation with 1222 DBS electrodes. Three patients (0.50%) experienced vascular complications.

CONCLUSION

This vascular complication rate is at the low end of that reported in the literature. Risk mitigation strategies discussed include a consistent neurosurgical team, dual methodology target and trajectory planning, control of cerebrospinal fluid egress during the procedure, use of a specialised microelectrode recording (MER)/macrostimulation electrode without an introducing brain cannula and low number of MER passes. A reduced vascular complication rate may improve the acceptability of DBS therapy for both patients and referrers.

摘要

目的

对于帕金森病(PD)患者,深部脑刺激(DBS)是一种有效的治疗方法,但目前使用不足,这些患者的震颤、运动波动和/或异动症无法通过口服药物治疗得到满意控制。对与手术相关的血管并发症的担忧仍然是转诊医生和患者不愿接受治疗的重要原因。我们回顾了在我们中心由单一神经科医生/神经外科团队治疗的首批600例帕金森病患者中血管并发症的发生率。

方法

对2001年至2023年间因帕金森病接受DBS植入治疗的患者常规收集的手术数据进行回顾性分析。详细分析血管并发症的发生率,并检查相关因果因素。

结果

包括再次植入,600例连续DBS患者共植入了1222个DBS电极。3例患者(0.50%)发生了血管并发症。

结论

该血管并发症发生率处于文献报道的较低水平。讨论的风险缓解策略包括由固定的神经外科团队进行手术、采用双重方法进行靶点和轨迹规划、术中控制脑脊液流出、使用不带导入脑套管的专用微电极记录(MER)/宏观刺激电极以及减少MER穿刺次数。降低血管并发症发生率可能会提高患者和转诊医生对DBS治疗的接受度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee4e/11529736/d2e3a801b25c/bmjno-6-2-g001.jpg

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