• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探索肝素对晚期糖基化终末产物诱导的内皮损伤的保护机制。

Exploring heparin's protective mechanism against AGEs induced endothelial injury.

作者信息

Shi Junfeng, Guan Yudong, Song Hongwei, Zhu Liang, Li Jingjing, Li Qinying, Hou Ningning, Han Fang, Wang Meng, Zhang Kexin, Shan Ming, Sun Xiaodong, Qiu Hongyan

机构信息

Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, Weifang, China.

Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China.

出版信息

iScience. 2024 Oct 3;27(11):111084. doi: 10.1016/j.isci.2024.111084. eCollection 2024 Nov 15.

DOI:10.1016/j.isci.2024.111084
PMID:39493878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11530820/
Abstract

Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug. This study investigated whether heparin could ameliorate AGEs-induced endothelial injury. Remarkably, heparin effectively attenuated this cellular damage and assumed a reparative role. Furthermore, heparin inhibited the AGEs-RAGE-NFκB axis, thereby mitigating endothelial inflammatory injury. Comprehensive proteome and knockdown experiments suggested that heparin may exert a positive influence on cell growth and further alleviate pathological damage by upregulating the expression of LYAR (cell growth-regulating nucleolar protein). Diabetic mouse model was also used to further verify the changes of endothelial tissue in diabetic state and heparin intervention. In summary, these findings demonstrate that heparin has the potential to ameliorate AGEs-induced endothelial injury, opening new avenues for exploring the expanded therapeutic roles of heparin and its potential application in the management of diabetes and its associated complications.

摘要

糖尿病中的晚期糖基化终末产物（AGEs）可导致内皮损伤。肝素作为一种公认的抗凝剂广为人知，它也是一种多功能治疗药物。本研究调查了肝素是否能改善AGEs诱导的内皮损伤。值得注意的是，肝素有效地减轻了这种细胞损伤并发挥了修复作用。此外，肝素抑制了AGEs-RAGE-NFκB轴，从而减轻了内皮炎症损伤。综合蛋白质组学和基因敲低实验表明，肝素可能通过上调LYAR（细胞生长调节核仁蛋白）的表达对细胞生长产生积极影响，并进一步减轻病理损伤。还使用糖尿病小鼠模型进一步验证糖尿病状态下内皮组织的变化以及肝素干预情况。总之，这些发现表明肝素具有改善AGEs诱导的内皮损伤的潜力，为探索肝素的扩展治疗作用及其在糖尿病及其相关并发症管理中的潜在应用开辟了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/7bfea53e15ff/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/e3467e52073d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/e2b069e2d3f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/03b2f0c60cf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/023c60194f69/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/294745fdb96c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/4359e1da1bd4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/72c188954780/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/4d7887313e42/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/7bfea53e15ff/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/e3467e52073d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/e2b069e2d3f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/03b2f0c60cf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/023c60194f69/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/294745fdb96c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/4359e1da1bd4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/72c188954780/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/4d7887313e42/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be76/11530820/7bfea53e15ff/gr8.jpg

相似文献

1
Exploring heparin's protective mechanism against AGEs induced endothelial injury.探索肝素对晚期糖基化终末产物诱导的内皮损伤的保护机制。
iScience. 2024 Oct 3;27(11):111084. doi: 10.1016/j.isci.2024.111084. eCollection 2024 Nov 15.
2
Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling.丹酚酸A通过抑制晚期糖基化终产物-晚期糖基化终产物受体（AGE-RAGE）信号通路改善肾小球内皮功能障碍，从而预防糖尿病肾病。
Cell Physiol Biochem. 2017;44(6):2378-2394. doi: 10.1159/000486154. Epub 2017 Dec 18.
3
Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway.京尼平通过线粒体代谢相关信号通路下调晚期糖基化终产物来缓解糖尿病视网膜病变。
World J Diabetes. 2023 Sep 15;14(9):1349-1368. doi: 10.4239/wjd.v14.i9.1349.
4
Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta.萝卜硫素可减轻晚期糖基化终末产物（AGEs）诱导的内皮细胞和大鼠主动脉炎症。
Nutr Metab Cardiovasc Dis. 2016 Sep;26(9):797-807. doi: 10.1016/j.numecd.2016.04.008. Epub 2016 Apr 21.
5
Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway.梓醇通过抑制RAGE/RhoA/ROCK信号通路改善糖尿病肾病中的内皮功能障碍和炎症。
Chem Biol Interact. 2021 Oct 1;348:109625. doi: 10.1016/j.cbi.2021.109625. Epub 2021 Aug 17.
6
Geniposide ameliorates diabetic nephropathy in type 2 diabetic mice by targeting AGEs-RAGE-dependent inflammatory pathway.栀子苷通过靶向 AGEs-RAGE 依赖的炎症通路改善 2 型糖尿病小鼠的糖尿病肾病。
Phytomedicine. 2024 Dec;135:156046. doi: 10.1016/j.phymed.2024.156046. Epub 2024 Sep 12.
7
Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells.硫代磷酸酯适体封闭晚期糖基化终产物诱导的培养周细胞和内皮细胞损伤。
Microvasc Res. 2013 Nov;90:64-70. doi: 10.1016/j.mvr.2013.08.010. Epub 2013 Sep 5.
8
The protective effect of Smilax glabra extract on advanced glycation end products-induced endothelial dysfunction in HUVECs via RAGE-ERK1/2-NF-κB pathway.土茯苓提取物通过RAGE-ERK1/2-NF-κB途径对晚期糖基化终产物诱导的人脐静脉内皮细胞功能障碍的保护作用。
J Ethnopharmacol. 2014 Aug 8;155(1):785-95. doi: 10.1016/j.jep.2014.06.028. Epub 2014 Jun 19.
9
Telmisartan inhibits advanced glycation end products (AGEs)-elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptor-gammaactivation.替米沙坦通过过氧化物酶体增殖物激活受体γ激活抑制晚期糖基化终末产物（AGEs）引发的内皮细胞损伤，其机制是抑制AGE受体（RAGE）的表达。
Protein Pept Lett. 2008;15(8):850-3. doi: 10.2174/092986608785203746.
10
Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine.N-乙酰-L-半胱氨酸抑制甲基乙二醛诱导的晚期糖基化终产物/晚期糖基化终产物受体表达对皮肤具有保护作用。
Cell Physiol Biochem. 2017;41(2):742-754. doi: 10.1159/000458734. Epub 2017 Feb 13.

本文引用的文献

1
Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform.Sangerbox：一个全面的、用户交互友好的临床生物信息学分析平台。
Imeta. 2022 Jul 8;1(3):e36. doi: 10.1002/imt2.36. eCollection 2022 Sep.
2
2'-5' oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability.2'-5'寡聚腺苷酸合成酶样蛋白 1（OASL1）通过维持内皮型一氧化氮合酶 mRNA 的稳定性来防止动脉粥样硬化。
Nat Commun. 2022 Nov 4;13(1):6647. doi: 10.1038/s41467-022-34433-z.
3
Effects of systemic anticoagulation in a murine model of compensatory lung growth.
系统抗凝对代偿性肺生长小鼠模型的影响。
Pediatr Res. 2023 Jun;93(7):1846-1855. doi: 10.1038/s41390-022-02323-1. Epub 2022 Oct 4.
4
Heparin: An old drug for new clinical applications.肝素：一种具有新临床应用的老药。
Carbohydr Polym. 2022 Nov 1;295:119818. doi: 10.1016/j.carbpol.2022.119818. Epub 2022 Jul 3.
5
Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study.循环 AGEs 水平和可溶性 RAGE 同种型与 2 型糖尿病的全因死亡率和心血管并发症的发生有关：一项回顾性队列研究。
Cardiovasc Diabetol. 2022 Jun 6;21(1):95. doi: 10.1186/s12933-022-01535-3.
6
Impact of low-molecular-weight heparin in the treatment of moderately severe and severe acute pancreatitis; a randomized, single blind, phase 3 control trial.低分子量肝素治疗中度重症和重症急性胰腺炎的疗效；一项随机、单盲、3期对照试验。
Int J Surg. 2022 May;101:106621. doi: 10.1016/j.ijsu.2022.106621. Epub 2022 Apr 27.
7
High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons.新冠病毒疾病中的高迁移率族蛋白B1（HMGB1）：危险关联的推断
Inflammopharmacology. 2022 Jun;30(3):811-820. doi: 10.1007/s10787-022-00988-y. Epub 2022 Apr 26.
8
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.蛋白激酶 N2 介导电切应力诱导的内皮型一氧化氮合酶激活和血管张力调节。
J Clin Invest. 2021 Nov 1;131(21). doi: 10.1172/JCI145734.
9
Comprehensive overview of human serum albumin glycation in diabetes mellitus.糖尿病患者血清白蛋白糖基化的综合概述
World J Diabetes. 2021 Jul 15;12(7):1057-1069. doi: 10.4239/wjd.v12.i7.1057.
10
Emerging Targets in Type 2 Diabetes and Diabetic Complications.2 型糖尿病及糖尿病并发症的新兴靶点。
Adv Sci (Weinh). 2021 Sep;8(18):e2100275. doi: 10.1002/advs.202100275. Epub 2021 Jul 28.