识别中国白血病儿童的症状类型、功能损害及其人口学特征：一项潜在剖面分析

Identifying Typologies of Symptoms and Functional Impairments in Chinese Children With Leukemia and Their Population Characteristics: A Latent Profile Analysis.

作者信息

Wang Jingting, Wu Xiaochen, Zhang Wen, Bi Xuanyi, Wang Yingwen, Yu Ling, Wu Huifang, Yang Qi, Huang Haiying, Wang Yanqing, Yuan Changrong

机构信息

Author Affiliations: School of Nursing, Naval Medical University (Dr Wang and Mr Bi); School of Nursing, Fudan University (Ms X. Wu and Drs Zhang and Yuan); Department of Nursing, Children's Hospital of Fudan University (Ms Y. W. Wang); and Department of Hematology & Oncology, Children's Hospital of Fudan University (Ms Yu), Shanghai, China; Department of Hematology, Children's Hospital of Soochow University, Suzhou, Jiangsu (Mss H. Wu and Yang); Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong (Ms Huang); and Department of Hematology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang (Ms Y. Q. Wang), China.

出版信息

Cancer Nurs. 2024 Nov 5. doi: 10.1097/NCC.0000000000001422.

DOI:10.1097/NCC.0000000000001422

PMID:39495041

Abstract

BACKGROUND

Symptom distress and functional impairments in children with leukemia directly affect their quality of life.

OBJECTIVES

To identify subgroups of symptom distress and functional impairments in Chinese children with leukemia and to examine the associations of the latent classes with individual characteristics.

METHODS

This multicenter cross-sectional survey study recruited children with leukemia who received chemotherapy in 4 hospitals in Shanghai, Jiangsu, Zhejiang, and Guangdong Province. The participants were surveyed via PROMIS-25 (Patient-Reported Outcomes Measurement Information System Pediatric-25 Profile). Latent profile analysis and multinomial logistic regression model were performed to identify subgroups of symptom distress and function impairments among children with leukemia.

RESULTS

Latent profile analysis results suggested the classification of 3 subgroups: profile 1: "moderate symptom distress, moderate mobility impairment with fair peer relationship function" group (69, 28.3%), profile 2: "mild symptom distress, no mobility impairment with good peer relationship function" group (97, 39.8%), and profile 3: "no symptom distress, no mobility impairment with good peer relationship function" group (78, 32.0%). Sociodemographic characteristics, including gender of the children, gender and marital status of the parents, average monthly income of the family, and reimbursement ratio of treatment expenses, had significant associations with the latent profile membership ( P < .05).

CONCLUSION

This study identified 3 distinct profiles of symptom distress and functional impairments in children with leukemia and found significant associations between these profiles and sociodemographic characteristics.

IMPLICATIONS FOR PRACTICE

The classification of the 3 latent profiles in children with leukemia helps to provide targeted supportive intervention to those children and their families.

摘要

背景

白血病患儿的症状困扰和功能障碍直接影响其生活质量。

目的

识别中国白血病患儿症状困扰和功能障碍的亚组，并检验潜在类别与个体特征之间的关联。

方法

这项多中心横断面调查研究招募了在上海、江苏、浙江和广东省4家医院接受化疗的白血病患儿。通过患者报告结局测量信息系统儿科25项简表（PROMIS-25）对参与者进行调查。采用潜在类别分析和多项逻辑回归模型来识别白血病患儿症状困扰和功能障碍的亚组。

结果

潜在类别分析结果显示分为3个亚组：类别1：“中度症状困扰、中度活动能力障碍且同伴关系功能良好”组（69例，28.3%），类别2：“轻度症状困扰、无活动能力障碍且同伴关系功能良好”组（97例，39.8%），类别3：“无症状困扰、无活动能力障碍且同伴关系功能良好”组（78例，32.0%）。社会人口学特征，包括患儿性别、父母性别和婚姻状况、家庭月平均收入以及治疗费用报销比例，与潜在类别归属存在显著关联（P<0.05）。