Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
J Alzheimers Dis. 2024 Nov;102(1):44-52. doi: 10.1177/13872877241284200. Epub 2024 Oct 10.
Evidence on associations of remnant cholesterol (RC) and its variability with cognitive function is still lacking.
To explore the association of RC and its variability with cognitive function.
Participants were recruited from a population-based cohort, the China Health and Retirement Longitudinal Study (CHARLS). Cognitive function was assessed by a standardized questionnaire from CHARLS, with domains of episodic memory and mental intactness. A linear mixed effects model was used to analyze the association of RC with cognitive function, along with its variability (calculated as standard deviation [SD], coefficient of variation [CV], variability independent of the mean [VIM]), with results expressed as β (95%CI). Potential subgroup differences in the association of RC and its variability with cognitive function were also explored.
4234 participants were eventually included, with mean (SD) age of 57.4 (8.0) years. Each 10 mg/dL increase in RC was associated with 0.053 (95%CI: 0.096, 0.009) points, 0.021 (95%CI: 0.042, 0.000) points, 0.032 (95%CI: 0.064, 0.001) points decrease in global cognitive function, episodic memory, and mental intactness scores, respectively. Compared with the first tertile (T1) group of RC variability (calculated as SD, VIM), T3 showed a lower level in global cognition and episodic memory after multivariate adjustment. The potential modification effects of educational level on RC and its variability in relation to cognitive function were also identified.
Among Chinese middle-aged and older adults, higher RC level were associated with worse cognitive function. Greater RC variability was also associated with worse cognitive performance, especially in memory function.
关于残余胆固醇（RC）及其变异性与认知功能的关联的证据仍然缺乏。
探讨 RC 及其变异性与认知功能的关系。
参与者来自一项基于人群的队列研究，即中国健康与退休纵向研究（CHARLS）。认知功能通过 CHARLS 的标准化问卷进行评估，包括情景记忆和心理健全度两个领域。采用线性混合效应模型分析 RC 与认知功能的关系，以及 RC 的变异性（以标准差[SD]、变异系数[CV]和均值独立变异[VIM]表示）与认知功能的关系，结果表示为β（95%CI）。还探讨了 RC 及其变异性与认知功能的关联在潜在亚组之间的差异。
最终纳入 4234 名参与者，平均（SD）年龄为 57.4（8.0）岁。RC 每增加 10 mg/dL，与全球认知功能、情景记忆和心理健全度得分分别降低 0.053（95%CI：0.096，0.009）、0.021（95%CI：0.042，0.000）和 0.032（95%CI：0.064，0.001）点相关。与 RC 变异性（SD、VIM）的第一三分位（T1）组相比，T3 组在经过多变量调整后，全球认知和情景记忆得分较低。还确定了教育水平对 RC 和其变异性与认知功能之间关系的潜在修饰作用。
在中国中老年人群中，较高的 RC 水平与较差的认知功能相关。较大的 RC 变异性也与较差的认知表现相关，尤其是在记忆功能方面。
