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从猫奶中分离并评估YH-15：潜在的益生菌作用和抗菌特性。

Isolation and evaluation of YH-15 from cat milk: Potential probiotic effects and antimicrobial properties.

作者信息

Li Yahui, Zhang Yiwen, Zhao Junxin, Zhang Xuan, Liu Shiwei, Qi Hanmeng, Qiao Fuqiang, Yao Hua

机构信息

Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.

Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine, China.

出版信息

Heliyon. 2024 Oct 18;10(20):e39539. doi: 10.1016/j.heliyon.2024.e39539. eCollection 2024 Oct 30.

DOI:10.1016/j.heliyon.2024.e39539
PMID:39498095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11533615/
Abstract

The study aimed to screen for the possible presence of lactic acid bacteria (LAB) in cat milk in order to evaluate their probiotic properties. The isolates were characterized by biochemical identification, morphological tests and 16S rDNA sequencing. Afterward, gastrointestinal passage, safety and probiotic properties were evaluated. The results showed that the isolates had 10 strains of permitted in the feed additive catalog. The high survival rate in the acid and bile salt resistance test reflected the good strain tolerance of the isolates to the simulated gastrointestinal conditions of the host . The mean inhibitory diameters of the 10 strains against chloramphenicol and tetracycline were 23.6 mm and 17.4 mm, respectively; none of the hemolytic tests showed α/β hemolytic ring. The bacteriostatic test showed that YH-9, YH-14 and YH-15 had inhibitory effects on four common pathogenic bacteria, including , , and . The adhesion test showed that YH-15 had good adhesion to HT-29 cells. Based on these results, we concluded that YH-15 extracted from cat milk has potential application as a clinical probiotic therapy and health care product.

摘要

该研究旨在筛查猫乳中可能存在的乳酸菌（LAB），以评估其益生菌特性。通过生化鉴定、形态学测试和16S rDNA测序对分离株进行表征。随后，评估了胃肠道通过率、安全性和益生菌特性。结果表明，分离株中有10株在饲料添加剂目录中允许使用。耐酸和耐胆盐试验中的高存活率反映了分离株对宿主模拟胃肠道条件的良好菌株耐受性。这10株菌对氯霉素和四环素的平均抑菌直径分别为23.6毫米和17.4毫米；所有溶血试验均未显示α/β溶血环。抑菌试验表明，YH-9、YH-14和YH-15对包括[此处原文缺失四种病原菌名称]在内的四种常见病原菌有抑制作用。黏附试验表明，YH-15对HT-29细胞有良好的黏附性。基于这些结果，我们得出结论，从猫乳中提取的YH-15作为临床益生菌疗法和保健品具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/db8bf596b7d2/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/8f7ebb932750/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/c5405fe71179/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/4b7ac023d441/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/d17480f5755e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/01695c06fc8d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/e37ba2e6c76e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/06bd3895c488/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/425664ec42ec/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/9e05df14468b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/db8bf596b7d2/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/8f7ebb932750/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/c5405fe71179/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/4b7ac023d441/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/d17480f5755e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/01695c06fc8d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/e37ba2e6c76e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/06bd3895c488/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/425664ec42ec/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/9e05df14468b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dde/11533615/db8bf596b7d2/gr10.jpg

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