Pandya Shreya, Jaafar Muhammed A, Han Kenneth D, Manion Garrett N, Moin Kayvon A, Zhang Stephanie, Moshirfar Majid, Hoopes Phillip C
Ophthalmology, University of Louisville School of Medicine, Louisville, USA.
Ophthalmology, University of Arizona College of Medicine - Phoenix, Phoenix, USA.
Cureus. 2024 Oct 6;16(10):e70943. doi: 10.7759/cureus.70943. eCollection 2024 Oct.
The aim is to assess for any lasting changes in corneal densitometry (CD) in patients who underwent small incision lenticule extraction (SMILE) and developed early transient postoperative corneal haze.
This retrospective chart review analyzed 98 eyes from 49 patients who underwent SMILE at the Hoopes Vision Clinic and had one-year postoperative Pentacam CD (Oculus Optikgeräte GmbH, Wetzlar, Germany). These were compared to 78 eyes from 42 unoperated myopic control patients with documented CD measurements. The preoperative CD, measured in grayscale units (GSU), was compared between SMILE patients who developed early transient haze ("transient haze group"), SMILE patients who did not build haze ("non-haze group"), and patients who did not undergo any refractive surgery ("controls"). The postoperative CD was compared between the transient haze and non-haze groups. Then, the postoperative CD was compared to the preoperative CD for the non-haze group and transient haze group, respectively.
The only significant difference in preoperative CD was in the central layer of the cornea at the 6-10 mm annulus between the non-haze group and controls (17.31 ±3.77 vs. 16.18 ±3.92 GSU; p=0.04). Postoperatively, there were no differences in CD between the non-haze group and the transient haze group (p<0.05). Comparing postoperative CD to preoperative CD, the non-haze group had increased CD in the 2-6 mm annulus of the anterior (1.54 ±0.45 GSU; p=0.001), posterior (0.65 ±2.28 GSU; p=0.032), and full thickness (0.72 ±0.29 GSU; p=0.006) layers of the cornea in addition to an increased CD in the 6-10 mm annulus of the posterior corneal layer (1.19 ±0.55 GSU; p=0.049). The transient haze group had an increased CD in the 2-6 mm annulus of the anterior (2.61 ±1.09 GSU; p=0.021) and full thickness (1.44 ±0.68 GSU; p=0.039) layers of the cornea.
There is no lasting difference in CD between patients who develop postoperative transient haze and those who do not after undergoing SMILE.
评估接受小切口透镜切除术（SMILE）并出现早期短暂性术后角膜混浊的患者角膜密度测量（CD）的任何持久变化。
这项回顾性病历审查分析了49例在Hoopes视力诊所接受SMILE手术且术后一年进行Pentacam CD测量（德国韦茨拉尔奥culus Optikgeräte GmbH公司）的患者的98只眼睛。将这些眼睛与42例有记录的CD测量值的未手术近视对照患者的78只眼睛进行比较。比较了出现早期短暂性混浊的SMILE患者（“短暂性混浊组”）、未出现混浊的SMILE患者（“无混浊组”）和未接受任何屈光手术的患者（“对照组”）术前以灰度单位（GSU）测量的CD。比较了短暂性混浊组和无混浊组的术后CD。然后，分别将无混浊组和短暂性混浊组的术后CD与术前CD进行比较。
术前CD的唯一显著差异在于无混浊组和对照组之间角膜中央层6 - 10 mm环带处（17.31±3.77 vs. 16.18±3.92 GSU；p = 0.04）。术后，无混浊组和短暂性混浊组之间的CD无差异（p<0.05）。将术后CD与术前CD进行比较，无混浊组除角膜后层6 - 10 mm环带处CD增加（1.19±0.55 GSU；p = 0.049）外，角膜前层2 - 6 mm环带处（1.54±0.45 GSU；p = 0.001）、后层（0.65±2.28 GSU；p = 0.032）和全层（0.72±0.29 GSU；p = 0.006）的CD也增加。短暂性混浊组角膜前层2 - 6 mm环带处（2.61±1.09 GSU；p = 0.021）和全层（1.44±0.68 GSU；p = 0.039）的CD增加。
接受SMILE手术后出现术后短暂性混浊的患者与未出现混浊的患者之间，CD没有持久差异。
