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胆碱能调节树突 Ca spikes 控制海马 CA3 锥体神经元的放电模式。

Cholinergic regulation of dendritic Ca spikes controls firing mode of hippocampal CA3 pyramidal neurons.

机构信息

Laboratory of Neuronal Signaling, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.

Doctoral College of Semmelweis University, János Szentágothai Neurosciences Division, Budapest 1085, Hungary.

出版信息

Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2321501121. doi: 10.1073/pnas.2321501121. Epub 2024 Nov 6.

DOI:10.1073/pnas.2321501121
PMID:39503887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572977/
Abstract

Active dendritic integrative mechanisms such as regenerative dendritic spikes enrich the information processing abilities of neurons and fundamentally contribute to behaviorally relevant computations. Dendritic Ca spikes are generally thought to produce plateau-like dendritic depolarization and somatic complex spike burst (CSB) firing, which can initiate rapid changes in spatial coding properties of hippocampal pyramidal cells (PCs). However, here we reveal that a morpho-topographically distinguishable subpopulation of rat and mouse hippocampal CA3PCs exhibits compound apical dendritic Ca spikes with unusually short duration that do not support the firing of sustained CSBs. These Ca spikes are mediated by L-type Ca channels and their time course is restricted by A- and M-type K channels. Cholinergic activation powerfully converts short Ca spikes to long-duration forms, and facilitates and prolongs CSB firing. We propose that cholinergic neuromodulation controls the ability of a CA3PC subtype to generate sustained plateau potentials, providing a state-dependent dendritic mechanism for memory encoding and retrieval.

摘要

活性树突整合机制，如再生树突峰，丰富了神经元的信息处理能力，并从根本上促进了与行为相关的计算。树突 Ca 峰通常被认为会产生类似平台的树突去极化和体细胞复杂尖峰爆发 (CSB) 放电，这可以引发海马锥体神经元 (PCs) 空间编码特性的快速变化。然而，在这里我们揭示了大鼠和小鼠海马 CA3PCs 的一个形态拓扑上可区分的亚群表现出具有异常短持续时间的复合顶树突 Ca 峰，这些 Ca 峰不支持持续 CSB 的放电。这些 Ca 峰是由 L 型钙通道介导的，其时间过程受到 A 型和 M 型钾通道的限制。胆碱能激活有力地将短 Ca 峰转换为长时程形式，并促进和延长 CSB 的放电。我们提出，胆碱能神经调制控制 CA3PC 亚型产生持续平台电位的能力，为记忆编码和检索提供了一种依赖于状态的树突机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/6304e40cc11c/pnas.2321501121fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/85e956f65a00/pnas.2321501121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/71bdac05cab0/pnas.2321501121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/c31b5ce3b235/pnas.2321501121fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/6304e40cc11c/pnas.2321501121fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/85e956f65a00/pnas.2321501121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/71bdac05cab0/pnas.2321501121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/c31b5ce3b235/pnas.2321501121fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0b/11572977/6304e40cc11c/pnas.2321501121fig04.jpg

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2
The Guide to Dendritic Spikes of the Mammalian Cortex In Vitro and In Vivo.《哺乳动物皮质树突棘的体外和体内研究指南》
Neuroscience. 2022 May 1;489:15-33. doi: 10.1016/j.neuroscience.2022.02.009. Epub 2022 Feb 17.
3
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4
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Elife. 2021 Oct 26;10:e65580. doi: 10.7554/eLife.65580.
5
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.跨岛叶和海马结构的转录组细胞类型分类学。
Cell. 2021 Jun 10;184(12):3222-3241.e26. doi: 10.1016/j.cell.2021.04.021. Epub 2021 May 17.
6
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