一种基于聚酰胺胺修饰的自增强电化学发光适体传感器 Zr-卟啉用于林可霉素的灵敏检测。
A self-enhanced electrochemiluminescence aptasensor Zr-porphyrin modified with polyamidoamine for sensitive detection of lincomycin.
机构信息
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China.
Scholl of Basic Courses, Bengbu Medical University, Bengbu 233030, PR China.
出版信息
Food Chem. 2025 Feb 1;464(Pt 3):141846. doi: 10.1016/j.foodchem.2024.141846. Epub 2024 Oct 29.
Exploring novel and sensitive analysis methods for monitoring lincomycin (Lin) residues is of great significance since overuse of it would cause a serious threat to public health. Herein, a Zr-porphyrin metal-organic frameworks (Zr-TCPP) with covalently modified polyamidoamine (PAMAM) dendrimers was synthesized as a novel intramolecular self-enhanced ECL reagent, which exhibited greatly improved ECL response due to the promotion of SO generation and the shortening of the electron transfer distance. Graphene oxide modified with gold nanoparticles (Au@GO) was synthesized as the quencher for the ECL sensor construction based on the quenching strategy. The present aptasensor achieved a wide linear range of 1.0 × 10 - 5.0 × 10 g/mL and a low detection limit of 1.7 fg/mL, which was applied for the determination of Lin in different real samples with satisfactory results.
探索新型、灵敏的林可霉素（Lin）残留监测分析方法具有重要意义，因为过量使用林可霉素会对公众健康造成严重威胁。在此，我们合成了一种具有共价修饰的聚酰胺胺（PAMAM）树枝状大分子的锆卟啉金属-有机骨架（Zr-TCPP）作为新型的分子内自增强电化学发光（ECL）试剂，由于 SO 生成的促进和电子转移距离的缩短，其 ECL 响应得到了极大的提高。基于猝灭策略，我们合成了金纳米粒子修饰的氧化石墨烯（Au@GO）作为 ECL 传感器构建的猝灭剂。该适配体传感器实现了 1.0×10-5.0×10 g/mL 的较宽线性范围和 1.7 fg/mL 的低检测限，可用于不同实际样品中林可霉素的测定，结果令人满意。
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