Mauclin Marion, Guillien Alicia, Niespodziana Katarzyna, Boudier Anne, Schlederer Thomas, Bajic Maja, Errhalt Peter, Borochova Kristina, Pin Isabelle, Gormand Frédéric, Vernet Raphaël, Bousquet Jean, Bouzigon Emmanuelle, Valenta Rudolf, Siroux Valérie
Université Grenoble Alpes, INSERM U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.
the Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna.
J Allergy Clin Immunol Glob. 2024 Sep 17;4(1):100342. doi: 10.1016/j.jacig.2024.100342. eCollection 2025 Feb.
Viral infections in childhood, especially to rhinovirus (RV) and respiratory syncytial virus (RSV), are associated with asthma inception and exacerbation. However, little is known about the role of RV- and RSV-specific antibodies in childhood versus adult asthma.
We sought to investigate associations between RV- and RSV-specific IgG levels and asthma phenotypes in children and adults.
The analysis included 1771 samples from participants of the Epidemiological Study on the Genetics and Environment of Asthma (530 children; age [mean ± SD], 11.1 ± 2.8, and 1241 adults; age [mean ± SD], 43.4 ± 16.7, among whom 274 and 498 had ever asthma, respectively). RSV- and RV-specific IgG levels were determined using microarrayed virus-derived antigens and peptides. Cross-sectional associations between standardized RSV- and RV-specific IgG levels and asthma phenotypes were estimated by multiple regression models.
In children, ever asthma was associated with higher IgG levels specific to RV, especially to RV-A and RV-C, and to RSV (adjusted odds ratios [95% CI] for a 1 - SD increase in IgG levels were 1.52 [1.16-1.99], 1.42 [1.10-1.83], and 1.24 [0.99-1.54], respectively). These associations were stronger for moderate to severe asthma than for mild asthma. Conversely in adults, ever asthma was associated with lower RV-A, RV-B, and RV-C IgG levels (adjusted odds ratios [95% CI] were 0.86 [0.74-0.99], 0.83 [0.73-0.95], and 0.85 [0.73-0.99], respectively).
Our results suggest that the association between respiratory virus-specific antibody levels and asthma varies during life, with asthma associated with higher levels of IgG to RSV, RV-A, and RV-C in children and lower levels of IgG responses to RV-A/B/C in adults.
儿童时期的病毒感染，尤其是鼻病毒（RV）和呼吸道合胞病毒（RSV）感染，与哮喘的发病和加重有关。然而，关于RV和RSV特异性抗体在儿童哮喘与成人哮喘中的作用，人们了解甚少。
我们试图研究儿童和成人中RV和RSV特异性IgG水平与哮喘表型之间的关联。
分析纳入了哮喘遗传与环境流行病学研究参与者的1771份样本（530名儿童；年龄[均值±标准差]，11.1±2.8岁；1241名成人；年龄[均值±标准差]，43.4±16.7岁，其中分别有274名和498名曾患哮喘）。使用微阵列病毒衍生抗原和肽测定RSV和RV特异性IgG水平。通过多元回归模型估计标准化RSV和RV特异性IgG水平与哮喘表型之间的横断面关联。
在儿童中，曾患哮喘与更高的RV特异性IgG水平相关，尤其是RV - A和RV - C特异性IgG以及RSV特异性IgG（IgG水平每增加1个标准差的调整比值比[95%可信区间]分别为1.52[1.16 - 1.99]、1.42[1.10 - 1.83]和1.24[0.99 - 1.54]）。这些关联在中重度哮喘中比在轻度哮喘中更强。相反，在成人中，曾患哮喘与较低的RV - A、RV - B和RV - C IgG水平相关（调整比值比[95%可信区间]分别为0.86[0.74 - 0.99]、0.83[0.73 - 0.95]和0.85[0.73 - 0.99]）。
我们的结果表明，呼吸道病毒特异性抗体水平与哮喘之间的关联在生命过程中有所不同，儿童哮喘与较高水平的RSV、RV - A和RV - C IgG相关，而成人哮喘与对RV - A/B/C的较低水平IgG反应相关
