分束器——一种提供放射治疗计划中每个控制点剂量的算法。

The BeamSplitter - An algorithm providing the dose per control point of radiation therapy treatment plans.

作者信息

Gaudreault Mathieu, Burton Alex, Panettieri Vanessa, Hardcastle Nicholas

机构信息

Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria 3000, Australia.

Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria 3000, Australia; Australian Radiation Protection and Nuclear Safety Agency (ARPANSA), Yallambie, Victoria 3085, Australia; School of Science, RMIT University, Melbourne, Victoria 3000, Australia.

出版信息

Phys Med. 2024 Dec;128:104845. doi: 10.1016/j.ejmp.2024.104845. Epub 2024 Nov 6.

DOI:10.1016/j.ejmp.2024.104845

PMID:39509933

Abstract

PURPOSE

Commercial radiation therapy treatment planning systems (TPS) provide the three-dimensional time-integrated planned dose distribution. A four-dimensional (4D) dose calculation is essential to minimise dose-rate effects on pacemaker or in total body irradiation treatment or for time-dependent patient-specific quality assurance. We introduce the BeamSplitter, an algorithm in a commercial TPS generating 4D dose calculation.

METHODS

Automation was performed with the Eclipse Scripting Application Programming Interface (ESAPI, v16, Varian Medical System). The accumulated and reference dose distributions of twenty-one patients treated in 2022 at our institution were compared. The patients were selected to cover a broad range of modulated delivery techniques and plan complexity, quantified with the average leaf pair opening (ALPO). The dose distributions were compared with gamma passing rates (γPR). Moreover, the mean absolute percentage error (MAPE) between accumulated and reference dose metrics (planning target volume (PTV) D99% / D95% in stereotactic / non-stereotactic treatment, organs at risk (OAR) D5cc / D0.03 cc, and mean dose) was calculated. Dose accumulation was validated by point dose measurement.

RESULTS

The ALPO ranged from 11.6 mm to 77 mm. The accumulated and reference dose distributions were similar (γPR > 90 % in all patients). The MAPE between reference and accumulated dose metrics was lower than 1 % in all cases. The average dose difference through time between the accumulated and measured dose was lower than our clinical tolerance of 3 %.

CONCLUSIONS

The BeamSplitter is the first validated algorithm generating a 4D dose calculation of radiation therapy treatment plans within a commercial TPS.

摘要

目的

商业放射治疗治疗计划系统（TPS）提供三维时间积分计划剂量分布。四维（4D）剂量计算对于将剂量率对起搏器的影响降至最低、在全身照射治疗中或用于时间依赖性患者特异性质量保证至关重要。我们引入了BeamSplitter，这是一种在商业TPS中生成4D剂量计算的算法。

方法

使用Eclipse脚本应用程序编程接口（ESAPI，v16，瓦里安医疗系统）实现自动化。比较了2022年在我们机构接受治疗的21名患者的累积剂量分布和参考剂量分布。选择这些患者以涵盖广泛的调制递送技术和计划复杂性，并用平均叶对开口（ALPO）进行量化。将剂量分布与伽马通过率（γPR）进行比较。此外，计算了累积剂量指标和参考剂量指标（立体定向/非立体定向治疗中的计划靶体积（PTV）D99%/D95%、危及器官（OAR）D5cc/D0.03cc和平均剂量）之间的平均绝对百分比误差（MAPE）。通过点剂量测量验证剂量累积。