文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Identification of Potential Biomarkers in Papillary Thyroid Carcinoma Based on Proteomics.

作者信息

Sun Yu, Sun Jiaxuan, Gao Xiaona, Shi Tiefeng, Wang Maoqing

机构信息

Department of Thyroid Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.

Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, People's Republic of China.

出版信息

Onco Targets Ther. 2024 Nov 3;17:905-923. doi: 10.2147/OTT.S465636. eCollection 2024.

DOI:10.2147/OTT.S465636
PMID:39513013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542476/
Abstract

BACKGROUND: To identify biomarkers of papillary thyroid carcinoma (PTC) and explore the possible pathogenic mechanism. METHODS: This study included five patients with PTC. Protein expression of cancer tissues and adjacent normal thyroid tissues from each patient were analyzed by TMT proteomics technology. Differentially expressed proteins were identified, and functional annotation of differentially expressed proteins was performed by bioinformatics and pathway enrichment analysis. RESULTS: A total of 639 differentially expressed proteins were identified, including 278 upregulated and 361 downregulated proteins. Six upregulated proteins were identified as potential specific markers of PTC. CONCLUSION: Differentially expressed proteins may represent new molecular markers of PTC. These differentially expressed proteins and the related pathways may provide new insights into the pathogenic mechanisms of PTC.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/0e1c7ebcc8aa/OTT-17-905-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/219aa3bbc3f3/OTT-17-905-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/602f63ed382a/OTT-17-905-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/d7288c34b63b/OTT-17-905-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/053904ca1ab0/OTT-17-905-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/331c79d41ce4/OTT-17-905-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/c214751c9f3b/OTT-17-905-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/1ce818673165/OTT-17-905-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/af8c30222540/OTT-17-905-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/e259e9204412/OTT-17-905-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/392f27769f20/OTT-17-905-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/0e1c7ebcc8aa/OTT-17-905-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/219aa3bbc3f3/OTT-17-905-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/602f63ed382a/OTT-17-905-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/d7288c34b63b/OTT-17-905-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/053904ca1ab0/OTT-17-905-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/331c79d41ce4/OTT-17-905-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/c214751c9f3b/OTT-17-905-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/1ce818673165/OTT-17-905-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/af8c30222540/OTT-17-905-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/e259e9204412/OTT-17-905-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/392f27769f20/OTT-17-905-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/11542476/0e1c7ebcc8aa/OTT-17-905-g0011.jpg

相似文献

[1]
Identification of Potential Biomarkers in Papillary Thyroid Carcinoma Based on Proteomics.

Onco Targets Ther. 2024-11-3

[2]
Proteomics profiling for the global and acetylated proteins of papillary thyroid cancers.

Proteome Sci. 2023-4-26

[3]
TMT-labeling Proteomics of Papillary Thyroid Carcinoma Reveal Invasive Biomarkers.

J Cancer. 2020-8-25

[4]
Identification of Differentially Expressed Genes Associated with Papillary Thyroid Carcinoma.

Comb Chem High Throughput Screen. 2020

[5]
Identification of differentially expressed genes and signaling pathways in papillary thyroid cancer: a study based on integrated microarray and bioinformatics analysis.

Gland Surg. 2021-2

[6]
PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma.

Biochem Biophys Res Commun. 2018-3-24

[7]
Identification of potential pathogenic candidates or diagnostic biomarkers in papillary thyroid carcinoma using expression and methylation profiles.

Oncol Lett. 2019-12

[8]
Network-based meta-analysis in the identification of biomarkers for papillary thyroid cancer.

Gene. 2018-4-3

[9]
The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.

Cell Physiol Biochem. 2018

[10]
Identification of key genes of papillary thyroid carcinoma by integrated bioinformatics analysis.

Biosci Rep. 2020-8-28

本文引用的文献

[1]
Pathology Laboratory Archives: Conservation Quality of Nucleic Acids and Proteins for NSCLC Molecular Testing.

J Pers Med. 2024-3-22

[2]
Impact of a centralized archive for pathology laboratories on the health system.

Pathol Res Pract. 2023-5

[3]
CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.

J Endocrinol Invest. 2023-3

[4]
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers.

Comput Struct Biotechnol J. 2022-6-18

[5]
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax.

Apoptosis. 2022-6

[6]
MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma.

J Transl Med. 2022-1-6

[7]
Secular Trends in the Epidemiologic Patterns of Thyroid Cancer in China Over Three Decades: An Updated Systematic Analysis of Global Burden of Disease Study 2019 Data.

Front Endocrinol (Lausanne). 2021

[8]
Upregulation of is Related to Immunity and Chemotherapy Resistance in Gastric Cancer.

Int J Gen Med. 2021-8-27

[9]
Cartilage oligomeric matrix protein affects the biological behavior of papillary thyroid carcinoma cells by activating the PI3K/AKT/Bcl-2 pathway.

J Cancer. 2021-1-15

[10]
Long-term outcomes of radiofrequency ablation for unifocal low-risk papillary thyroid microcarcinoma: a large cohort study of 414 patients.

Eur Radiol. 2021-2

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索