Martire Francesco Giuseppe, d'Abate Claudia, Schettini Giorgia, Cimino Giulia, Ginetti Alessandro, Colombi Irene, Cannoni Alberto, Centini Gabriele, Zupi Errico, Lazzeri Lucia
Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, Strada delle Scotte 14, 53100 Siena, Italy.
Diagnostics (Basel). 2024 Oct 22;14(21):2344. doi: 10.3390/diagnostics14212344.
Adenomyosis is a chronic, hormone-related disease characterized by the presence of the endometrial glands and stroma within the myometrium. This condition can manifest in various features, focal or diffuse adenomyosis or as an adenomyoma, and it may involve different uterine walls (posterior, anterior, and/or lateral walls). The disease can also be classified into different degrees, as mild, moderate and severe, which can be associated with more intense symptoms, although this correlation is not always directly proportional. In fact, adenomyosis can be asymptomatic in about a third of cases or it can significantly impact patients' quality of life through painful symptoms, such as dysmenorrhea and dyspareunia, abnormal uterine bleeding-particularly heavy menstrual bleeding-and potential effects on fertility. Historically, adenomyosis has been considered a disease primarily affecting premenopausal women over the age of 40, often multiparous, because the diagnosis was traditionally based on surgical reports from hysterectomies performed after the completion of reproductive desire. Data on the presence of adenomyosis in adolescent patients remain limited. However, in recent years, advancements in noninvasive diagnostic tools and increased awareness of this pathology have enabled earlier diagnoses. The disease appears to have an early onset during adolescence, with a tendency to progress in terms of extent and severity over time. Adenomyosis often coexists with endometriosis, which also has an early onset. Therefore, it is important, when diagnosing adenomyosis, to also screen for concomitant endometriosis, especially deep endometriosis in the posterior compartment. The aim of this narrative review is to investigate the prevalence of different types and degrees of adenomyosis in younger patients, assess the associated symptoms, and describe the most appropriate diagnostic procedures for effective therapeutic management and follow-up, with the goal of improving the quality of life for these young women.
子宫腺肌病是一种与激素相关的慢性疾病,其特征是子宫肌层内存在子宫内膜腺体和间质。这种病症可表现为多种形式,如局灶性或弥漫性子宫腺肌病或腺肌瘤,并且可能累及不同的子宫壁(后壁、前壁和/或侧壁)。该疾病也可分为轻度、中度和重度不同程度,虽然这种关联并不总是成正比,但程度较重时可能伴有更强烈的症状。事实上,约三分之一的子宫腺肌病患者可能无症状,或者它可通过痛经、性交困难等疼痛症状、异常子宫出血(尤其是月经过多)以及对生育的潜在影响,显著影响患者的生活质量。从历史上看,子宫腺肌病一直被认为主要影响40岁以上的绝经前女性,且多产,因为传统诊断基于生殖意愿完成后进行的子宫切除手术报告。关于青少年患者子宫腺肌病存在情况的数据仍然有限。然而,近年来,非侵入性诊断工具的进步以及对这种病理状况认识的提高使得能够更早地诊断。该疾病似乎在青春期早期发病,并且随着时间的推移,在范围和严重程度上有进展的趋势。子宫腺肌病常与同样在青春期早期发病的子宫内膜异位症共存。因此,在诊断子宫腺肌病时,筛查是否合并子宫内膜异位症很重要,尤其是后盆腔深部子宫内膜异位症。本叙述性综述的目的是调查年轻患者中不同类型和程度子宫腺肌病的患病率,评估相关症状,并描述最适合有效治疗管理和随访的诊断程序,以期改善这些年轻女性的生活质量。