Department of Food and Nutrition, Chungbuk National University, Chungdae-ro 1, Seowon-gu, Cheongju 28644, Republic of Korea.
Int J Mol Sci. 2024 Oct 26;25(21):11524. doi: 10.3390/ijms252111524.
Time-restricted feeding (TRF) has emerged as a promising dietary approach for improving metabolic parameters associated with obesity. However, it remains largely unclear whether TRF offers benefits for obesity related to exposure to light at night. This study examined whether lean and obese mice under chronic light exposure could benefit from TRF intervention. Six-week-old C57BL/6 male mice were fed either a low-fat diet or a high-fat diet under a 12 h light/12 h dark cycle for 6 weeks. They were then divided into three subgroups: control light, chronic 24 h light, and chronic light with a daily 10 h TRF. Chronic light exposure led to increased weight gain and higher expression of inflammatory and fibrotic markers in the adipose tissue of both lean and obese mice. It also increased hepatic triglyceride content in mice, regardless of their weight status. TRF protected both lean and obese mice from weight gain, normalized inflammatory and fibrotic gene expression, and reduced adipose tissue collagen and liver triglyceride accumulation caused by light exposure alone or in combination with obesity. These results suggest that TRF could have clinical implications for preventing obesity associated with night shift work, regardless of current weight status.
限时进食（TRF）已成为改善与肥胖相关的代谢参数的一种有前途的饮食方法。然而，TRF 是否对与夜间暴露相关的肥胖有益仍然很大程度上不清楚。本研究探讨了慢性光照暴露下的瘦鼠和肥胖鼠是否可以从 TRF 干预中受益。将 6 周龄 C57BL/6 雄性小鼠在 12 小时光照/12 小时黑暗周期下分别用低脂饮食或高脂饮食喂养 6 周。然后将它们分为三组：对照光照组、慢性 24 小时光照组和慢性光照加每日 10 小时 TRF 组。慢性光照暴露导致瘦鼠和肥胖鼠的脂肪组织中体重增加和炎症及纤维化标志物表达增加。无论体重状况如何，TRF 还增加了小鼠肝脏中的甘油三酯含量。TRF 可防止瘦鼠和肥胖鼠体重增加，使炎症和纤维化基因表达正常化，并减少单独或与肥胖相结合的光照引起的脂肪组织胶原和肝脏甘油三酯堆积。这些结果表明，TRF 可能对预防与夜班工作相关的肥胖具有临床意义，无论当前体重状况如何。
