Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, OH, Columbus, USA.
School of Public Health, University of Saskatchewan, Saskatoon, Canada.
Virol J. 2024 Nov 9;21(1):285. doi: 10.1186/s12985-024-02557-x.
The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study, Zika virus was identified as ZAP-resistant and not sensitive to ZAP antiviral activity. Here, we found that ZAP was associated with the inhibition of Zika virus in Vero cells, in the absence of a robust type I IFN system because Vero cells are deficient for IFN-alpha and -beta. Also, quantitative RNA-seq data indicated that endogenous ZAP is associated with altered global gene expression both in the steady state and during Zika virus infection. Further studies are warranted to elucidate this IFN-alpha and -beta independent anti-Zika virus activity and involvement of ZAP.
锌指抗病毒蛋白 1（ZAP）具有广泛的抗病毒活性。ZAP 是一种干扰素（IFN）刺激基因，它本身可以增强 I 型 IFN 的抗病毒反应。在之前的一项研究中，寨卡病毒被鉴定为 ZAP 抗性，对 ZAP 的抗病毒活性不敏感。在这里，我们发现 ZAP 与 Vero 细胞中寨卡病毒的抑制有关，在没有强大的 I 型 IFN 系统的情况下，因为 Vero 细胞缺乏 IFN-α和-β。此外，定量 RNA-seq 数据表明，内源性 ZAP 与寨卡病毒感染期间和感染前后的全球基因表达改变有关。需要进一步的研究来阐明这种 IFN-α和-β 非依赖性抗寨卡病毒活性和 ZAP 的参与。
