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对于Lenke 1A青少年特发性脊柱侧凸,脊柱侧弯手术后植入物密度降低导致矫正丢失的区域:一项多中心研究。

Zones where reduced implant density leads to correction loss after scoliosis surgery for Lenke 1A adolescent idiopathic scoliosis: a multicenter study.

作者信息

Yanagisawa Kaho, Oba Hiroki, Ohba Tetsuro, Banno Tomohiro, Seki Shoji, Uehara Masashi, Ikegami Shota, Mimura Tetsuhiko, Hatakenaka Terue, Miyaoka Yoshinari, Kurogochi Daisuke, Fukuzawa Takuma, Koseki Michihiko, Kawaguchi Yoshiharu, Haro Hirotaka, Matsuyama Yukihiro, Takahashi Jun

机构信息

Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Department of Orthopaedic Surgery, Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

出版信息

Spine Deform. 2025 Mar;13(2):587-594. doi: 10.1007/s43390-024-01005-8. Epub 2024 Nov 11.

Abstract

PURPOSE

Investigate zones where implant density should not be reduced in posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) Lenke type 1A curves.

METHODS

126 consecutive patients (118 female and 8 male; mean age: 15.1 ± 2.2 years) with Lenke type 1A AIS who underwent PSF using pedicle screw constructs were included. Correction loss which was calculated using immediately postoperative and 2-year postoperative Cobb angle. Implant density was assessed by dividing the instrumented levels into four zones each on the concave and convex sides. The risk factors for significant correction loss were examined using logistic regression analysis. For convex apical zone, correction loss was compared among the three groups of low (0-59%), medium (60-99%), and high (100%) implant density.

RESULTS

Multivariate analysis revealed the apical zone of the convex side (Odds ratio [OR] 1.27; 95% confidence interval [CI] 1.01-1.59; P = 0.04) and the peri-apical zone of the convex side (OR 1.33; 95% CI 1.11-1.59; P = 0.002) as independent predictors of significant correction loss. In the convex apical zone, the median (interquartile range) correction loss of the low implant density, medium implant density, and high implant-density groups was 4.8° (1.5°), 5.3° (0.8°), and 2.2° (0.3°), respectively. The median difference was 2.6° (P = 0.048) between the low implant density and high implant-density group and 3.1° (P < 0.001) between the medium implant density and high implant-density group.

CONCLUSION

In PSF for AIS Lenke 1A, low implant density in the convex apical zones were significant factors affecting correction loss at 2 years postoperatively. However, the difference in correction loss between groups may not be large enough to consider clinically meaningful. Prospective studies of longer term outcomes are needed to determine whether these results are clinically important.

摘要

目的

研究青少年特发性脊柱侧凸(AIS)Lenke 1A型曲线后路脊柱融合术(PSF)中不应降低植入物密度的区域。

方法

纳入126例连续接受使用椎弓根螺钉结构进行PSF的Lenke 1A型AIS患者(118例女性,8例男性;平均年龄:15.1±2.2岁)。使用术后即刻和术后2年的Cobb角计算矫正丢失。通过将植入节段在凹侧和凸侧各分为四个区域来评估植入物密度。使用逻辑回归分析检查显著矫正丢失的危险因素。对于凸侧顶椎区,比较低(0 - 59%)、中(60 - 99%)、高(100%)植入物密度三组的矫正丢失情况。

结果

多因素分析显示凸侧顶椎区(优势比[OR]1.27;95%置信区间[CI]1.01 - 1.59;P = 0.04)和凸侧顶椎周围区(OR 1.33;95% CI 1.11 - 1.59;P = 0.002)是显著矫正丢失的独立预测因素。在凸侧顶椎区,低植入物密度组、中植入物密度组和高植入物密度组的中位数(四分位间距)矫正丢失分别为4.8°(1.5°)、5.3°(0.8°)和2.2°(0.3°)。低植入物密度组与高植入物密度组之间的中位数差异为2.6°(P = 0.048),中植入物密度组与高植入物密度组之间的中位数差异为3.1°(P < 0.001)。

结论

在AIS Lenke 1A的PSF中,凸侧顶椎区低植入物密度是影响术后2年矫正丢失的重要因素。然而,组间矫正丢失的差异可能不够大,以至于在临床上没有意义。需要进行长期结局的前瞻性研究来确定这些结果在临床上是否重要。

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