Hoang Gia-Huy L, Hecker Kent G, Maxey Connor, Burles Ford, Krigolson Olave E, Kopala-Sibley Daniel C
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Feb;10(2):148-157. doi: 10.1016/j.bpsc.2024.10.017. Epub 2024 Nov 9.
Reduced reward positivity (RewP), an electroencephalography marker elicited by feedback indicating reward, has been associated with an increased risk for depression during adolescence. However, the ability of the RewP to predict the first-lifetime onset of depressive disorders, as opposed to anxiety and suicidal ideation in high-risk populations, has not been thoroughly investigated. In this study, we examined whether the RewP predicts the first-lifetime onset of depression, anxiety, and suicidal ideation over 18 months in familial high-risk adolescents.
The sample included 145 adolescents (64.8% female), ages 11 to 17 years, who had at least 1 parent with a history of mood or anxiety disorders and completed baseline and at least 1 follow-up measurement. At baseline, the RewP was measured using a simple gambling task; current internalizing symptoms were assessed using self-report questionnaires; and the adolescent's psychiatric diagnoses were evaluated with diagnostic interviews. The same interview was administered to the adolescents again 9 months and 18 months later.
Logistic regression models showed that higher RewP scores significantly predicted a lower likelihood of developing a first onset of major depressive disorder over 18 months, even after controlling for sex, age, and baseline internalizing symptoms. In contrast, the RewP did not significantly predict the first onset of anxiety disorders or suicidal ideation.
A reduced RewP precedes the first onset of depression in high-risk adolescents, highlighting the RewP's predictive capability for depression risk in predisposed populations. A blunted RewP could complement self-reported symptoms in screening and prevention.
奖赏正性降低（RewP）是一种由表明奖赏的反馈所引发的脑电图标记物，与青少年期患抑郁症的风险增加有关。然而，RewP预测抑郁障碍首次终生发作的能力，与高危人群中的焦虑和自杀意念相对比，尚未得到充分研究。在本研究中，我们考察了RewP是否能预测家族高危青少年在18个月内抑郁、焦虑和自杀意念的首次终生发作。
样本包括145名年龄在11至17岁之间的青少年（64.8%为女性），他们至少有1名父母有情绪或焦虑障碍史，并完成了基线和至少1次随访测量。在基线时，使用简单赌博任务测量RewP；使用自我报告问卷评估当前的内化症状；并通过诊断访谈评估青少年的精神科诊断。在9个月和18个月后再次对青少年进行相同的访谈。
逻辑回归模型显示，即使在控制了性别、年龄和基线内化症状后，较高的RewP分数仍显著预测在18个月内首次发作重度抑郁症的可能性较低。相比之下，RewP并未显著预测焦虑障碍或自杀意念的首次发作。
高危青少年在首次发作抑郁症之前存在RewP降低，这突出了RewP在易感人群中对抑郁风险的预测能力。减弱的RewP可以在筛查和预防中补充自我报告的症状。
