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巴基斯坦的炎症性肠病:患病率低还是诊断不足?

Inflammatory bowel disease in Pakistan: Low prevalence or underdiagnosis?

作者信息

Zaman Zubia, Majid Zain

机构信息

Dr. Ruth K. M. Pfau Civil Hospital Karachi, Civil Hospital Karachi, Karachi 74100, Sindh, Pakistan.

Department of Gastroenterology, Sindh Institute of Urology and Transplantation, Karachi 75500, Pakistan.

出版信息

World J Gastrointest Pharmacol Ther. 2024 Nov 5;15(6):99226. doi: 10.4292/wjgpt.v15.i6.99226.

DOI:10.4292/wjgpt.v15.i6.99226
PMID:39534522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11551619/
Abstract

Inflammatory bowel disease (IBD) has a low prevalence in the Global South, including Pakistan. While genetics and gut flora, influenced by diet and the environment, can contribute to this, we are exploring the possibility of underdiagnosis. Lack of facilities trained in IBD, scarcity of medications, limited health insurance for specialist referral and the current epidemic of abdominal tuberculosis could be the cause. The increasing diagnosis of IBD among Pakistani immigrants and colorectal carcinoma among the young population might be the result of this. Timely referrals by primary care physicians to gastroenterologists, along with the growing use of newer technologies such as abdominal ultrasound for diagnosis can help mitigate the challenge of low or late diagnosis of this chronic condition.

摘要

炎症性肠病(IBD)在包括巴基斯坦在内的全球南方地区发病率较低。虽然受饮食和环境影响的遗传因素和肠道菌群可能导致这种情况,但我们正在探讨诊断不足的可能性。缺乏IBD相关培训设施、药物短缺、专科转诊的医疗保险有限以及当前腹部结核病的流行可能是原因所在。巴基斯坦移民中IBD诊断率的上升以及年轻人群中结直肠癌发病率的上升可能就是由此导致的。初级保健医生及时将患者转诊给胃肠病学家,以及越来越多地使用腹部超声等新技术进行诊断,有助于缓解这种慢性病诊断不足或诊断延迟的挑战。

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本文引用的文献

1
Strategies for Enhancing Inflammatory Bowel Disease Care in Pakistan: Bridging Gaps and Building Capacities.加强巴基斯坦炎症性肠病护理的策略:弥合差距与建设能力
Crohns Colitis 360. 2024 Apr 22;6(2):otae027. doi: 10.1093/crocol/otae027. eCollection 2024 Apr.
2
Evaluation of Factors Contributing to Diagnosis of Crohn's Disease in the Face of Increasing Trend in Pakistan.巴基斯坦克罗恩病诊断相关因素评估:面对发病率上升趋势的研究
Crohns Colitis 360. 2024 Mar 22;6(1):otae015. doi: 10.1093/crocol/otae015. eCollection 2024 Jan.
3
Sigmoidoscopic extent of ulcerative colitis and associated factors in Pakistani population.巴基斯坦人群中溃疡性结肠炎的乙状结肠镜检查范围及相关因素
Pak J Med Sci. 2022 Jan-Feb;38(1):276-280. doi: 10.12669/pjms.38.1.4648.
4
Incidence and Prevalence of Inflammatory Bowel Disease across Asia.亚洲炎症性肠病的发病率和患病率。
Yonsei Med J. 2021 Feb;62(2):99-108. doi: 10.3349/ymj.2021.62.2.99.
5
Spectrum of Preneoplastic and Neoplastic lesions of intestine in a Tertiary Care Hospital of Karachi, Pakistan.巴基斯坦卡拉奇一家三级医疗医院肠道癌前病变和肿瘤性病变的谱系
Pak J Med Sci. 2020 Jan-Feb;36(2):75-79. doi: 10.12669/pjms.36.2.687.
6
Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific.人群密度与炎症性肠病风险:亚太地区 13 个国家或地区的前瞻性人群研究
Am J Gastroenterol. 2019 Jan;114(1):107-115. doi: 10.1038/s41395-018-0233-2.