TEX264介导的选择性自噬指导DNA损伤修复。
TEX264-mediated selective autophagy directs DNA damage repair.
作者信息
Qi Yuxia, Suzuki Sho W
机构信息
School of Biological Sciences, Nanyang Technological University, Singapore.
School of Biological Sciences, Nanyang Technological University, Singapore.
出版信息
Trends Biochem Sci. 2025 Jan;50(1):4-5. doi: 10.1016/j.tibs.2024.10.012. Epub 2024 Nov 15.
DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy.
DNA 不断受到内源性和外源性因素的损害，从而导致突变和疾病。虽然传统上认为 DNA 在细胞核中进行修复，但拉斯科等人揭示了溶酶体在 DNA 修复中的新作用，证明拓扑异构酶 1（TOP1）切割复合物（TOP1cc）的 DNA 损伤是通过 TEX264 介导的选择性自噬进行降解的。
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