Jimenez Sylvia, Powell Reuben P, Rincon Liliana, Clement Cecilia
John Sealy School of Medicine, University of Texas Medical Branch, Galveston, USA.
Pathology, University of Texas Medical Branch, Galveston, USA.
Cureus. 2024 Oct 16;16(10):e71646. doi: 10.7759/cureus.71646. eCollection 2024 Oct.
Molluscum contagiosum (MC) virus is a poxvirus that infects epidermal keratinocytes producing cutaneous nodules with characteristic intracytoplasmic inclusions. Intradermal nevus is a benign lesion that typically presents as clusters of melanocytes within the dermal layer of skin. Although both MC and melanocytic nevus are common lesions, MC arising within a melanocytic nevus is a rare event with only a few cases published in the literature. Herein, we report the case of a 64-year-old immunocompetent woman with an MC emerging within an intradermal nevus of the left nasolabial fold. In addition, the disappearance of most dermal melanocytes adjacent to the site of the MC infection was noted. This is a rarely reported event, and it has been suggested that it involves a mechanism of viral oncolysis among others, with potential implications for treatment and a need for further investigation.
传染性软疣病毒是一种痘病毒，可感染表皮角质形成细胞，产生具有特征性胞质内包涵体的皮肤结节。皮内痣是一种良性病变，通常表现为皮肤真皮层内的黑素细胞簇。虽然传染性软疣和黑素细胞痣都是常见病变，但在黑素细胞痣内出现传染性软疣是一种罕见事件，文献中仅报道了少数病例。在此，我们报告一例64岁免疫功能正常的女性，其左侧鼻唇沟皮内痣内出现了传染性软疣。此外，还注意到与传染性软疣感染部位相邻的大多数真皮黑素细胞消失。这是一个鲜有报道的事件，有人认为这涉及病毒溶瘤等机制，对治疗有潜在影响，需要进一步研究。
