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使用前列腺特异性抗原(PSA)检测进行前列腺癌筛查:一项回顾性研究。

Prostate cancer screening with Prostate-Specific Antigen (PSA) testing: A retrospective study.

作者信息

Goktas Olgun

机构信息

Dr. Olgun Goktas Associate Professor, Uludag University Family Health Center, Nilufer, Bursa, Turkey.

出版信息

Pak J Med Sci. 2024 Nov;40(10):2324-2330. doi: 10.12669/pjms.40.10.8558.

Abstract

OBJECTIVE

To evaluate the results of the prostate-specific antigen (PSA) test used in prostate cancer screening.

METHODS

This retrospective study was conducted on a total of 1106 male individuals, including 615 people (55.6%) aged 40-54, 379 people (34.3%) aged 55-69, and 112 individuals (10.1%) aged 70 and over. In the study, prostate-specific antigen (PSA) blood test results were performed on a total of 1106 male individuals aged 40 and over registered in the Uludag University Family Health Center, Bursa, Turkey during the 5-years between June 1, 2018, and May 31, 2023, were taken from the database and analyzed. Relationships with sociodemographic characteristics, comorbidities, and risk factors were examined. Data was analyzed using SPSS 25.

RESULTS

About 15.5% of the participants were married, 78.4% were single, and 6% were separated from their spouses or widows. The PSA values of the patients referred to the urologist were found to be significantly different between the ages of 55 and 69. It was determined that the PSA levels of the patients with benign prostatic hypertrophy and prostate cancer were higher than the patients without any finding, and the mean was 6.81±4.39 (p=0.01).

CONCLUSION

In our study, it is important to diagnose benign prostatic hypertrophy or prostate cancer in patients aged 55-69 years, whose mean PSA levels were 6.81±4.39, and referred to a urologist. As a contribution to the discussions in the literature, we recommend that the patient with symptoms be referred to the urologist after the test request and the joint decision with the family physician.

摘要

目的

评估用于前列腺癌筛查的前列腺特异性抗原(PSA)检测结果。

方法

本回顾性研究共纳入1106名男性个体,其中40 - 54岁者615人(55.6%),55 - 69岁者379人(34.3%),70岁及以上者112人(10.1%)。研究中,对2018年6月1日至2023年5月31日期间在土耳其布尔萨乌鲁达大学家庭健康中心登记的1106名40岁及以上男性个体进行了前列腺特异性抗原(PSA)血液检测,检测结果从数据库中提取并进行分析。研究了其与社会人口学特征、合并症和危险因素的关系。数据采用SPSS 25进行分析。

结果

约15.5%的参与者已婚,78.4%为单身,6%与配偶分居或丧偶。转诊至泌尿科医生的患者的PSA值在55至69岁之间存在显著差异。确定良性前列腺增生和前列腺癌患者的PSA水平高于无任何异常发现的患者,平均值为6.81±4.39(p = 0.01)。

结论

在我们的研究中,对于平均PSA水平为6.81±4.39且转诊至泌尿科医生的55 - 69岁患者,诊断良性前列腺增生或前列腺癌很重要。作为对文献讨论的贡献,我们建议有症状的患者在进行检测请求并与家庭医生共同决定后转诊至泌尿科医生。

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