The Predictive Value of NLR, PLR and SII for SSNHL in Children and Young Adults.

UNLABELLED

Sudden Sensorineural Hearing Loss is a common emergency in otolaryngology, with an increasing incidence among younger age groups. This study retrospectively analyzes peripheral blood inflammatory markers in SSNHL patients under 24 years-old to explore the potential prognostic value of the immune inflammatory response in young SSNHL patients. This retrospective analysis included 53 SSNHL patients who received treatment from January 2016 to December 2023. Patients were grouped based on age, gender, and therapeutic effects. Sixty-two healthy volunteers were selected from the hospital physical examination center as the control group. Neutrophil, lymphocyte, and platelet counts were measured to calculate the Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Systemic Immune-Inflammation Index (SII). Logistic regression models determined prognostic risk variables, and receiver operating characteristic (ROC) curves calculated the model's predictive accuracy. Compared to the control group, SSNHL patients exhibited increased absolute neutrophil counts, platelet counts, NLR, PLR, and SII, while lymphocyte counts decreased. Male patients showed statistical differences in neutrophil counts, NLR, PLR, and SII, while female patients showed statistical differences in neutrophil counts, NLR, and SII. Statistical differences were observed in platelet counts between males aged ≤ 18 and lymphocyte counts in males aged 18-24. Significant differences in neutrophil counts, NLR, and SII were found between effective and ineffective treatment groups for SSNHL patients aged 18-24. Elevated SII was identified as a risk factor affecting the efficacy of SSNHL treatment in patients aged 18-24. Chronic inflammation is a confirmed pathological and physiological process in SSNHL, necessitating hormone anti-inflammatory therapy for both adults and children.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s12070-024-04985-1.