Ouyang Fengshan, Chen Sheng, Li Shuhuan, Liu Lanyuan, Guan Senhong, Yan Zhaohan, Wu Shumin, Zeng Yunying, Liu Jiemei, Zhong Jiankai
Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, People's Republic of China.
Department of Rehabilitation Medicine, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, People's Republic of China.
Int J Gen Med. 2024 Nov 15;17:5273-5284. doi: 10.2147/IJGM.S483793. eCollection 2024.
This study aimed to examine the correlation and prognostic value of serum irisin levels in acute ischaemic stroke (AIS) and the subsequent development of hemiplegia.
This study recruited participants from the Department of Neurology and Rehabilitation Medicine at Shunde Hospital, Southern Medical University. The Fugl-Meyer Assessment was used to assess functional impairment. Serum irisin levels were measured using the enzyme-linked immunosorbent assay method. Multivariate logistic regression was employed to explore the factors related to serum irisin levels and AIS.
Serum irisin levels in the AIS group were significantly lower than those in the control group. However, no significant association was observed between serum irisin and stroke severity within the AIS cohort. Multivariate logistic regression analysis revealed an inverse correlation between serum irisin levels and AIS risk, indicating that it serves as a protective factor against AIS. The increase in serum irisin levels (adjusted odds ratio (OR) 0.938, 95% confidence interval [CI]: 0.899-0.977 per 100 pg/mL increment) was associated with a decreased risk of AIS. Analysis of the receiver operating characteristic curve confirmed the diagnostic value of serum irisin for AIS, with the area under the curve being 0.591 (95% CI: 0.522-0.659, = 0.012).
Serum irisin levels were significantly lower in AIS and were identified as a protective factor, suggesting that serum irisin may have diagnostic value for AIS.
本研究旨在探讨急性缺血性卒中（AIS）患者血清鸢尾素水平与随后偏瘫发生之间的相关性及预后价值。
本研究招募了南方医科大学顺德医院神经内科和康复医学科的参与者。采用Fugl-Meyer评估法评估功能障碍。采用酶联免疫吸附测定法测量血清鸢尾素水平。采用多因素逻辑回归分析探讨与血清鸢尾素水平及AIS相关的因素。
AIS组血清鸢尾素水平显著低于对照组。然而，在AIS队列中，未观察到血清鸢尾素与卒中严重程度之间存在显著关联。多因素逻辑回归分析显示血清鸢尾素水平与AIS风险呈负相关，表明其为AIS的保护因素。血清鸢尾素水平升高（每增加100 pg/mL，调整后的比值比（OR）为0.938，95%置信区间[CI]：0.899-0.977）与AIS风险降低相关。对受试者工作特征曲线的分析证实了血清鸢尾素对AIS的诊断价值，曲线下面积为0.591（95%CI：0.522-0.659，P = 0.012）。
AIS患者血清鸢尾素水平显著降低，并被确定为保护因素，提示血清鸢尾素可能对AIS具有诊断价值。
