Wu Qian, Geng Ziang, Lu Jun, Wang Shisong, Yu Zhongxue, Wang Siqi, Ren Xiaolin, Guan Shu, Liu Tiancong, Zhu Chen
Department of Neurology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Front Neurosci. 2024 Nov 5;18:1467562. doi: 10.3389/fnins.2024.1467562. eCollection 2024.
Neddylation, a type of protein post-translational modification that links the ubiquitin-like protein NEDD8 to substrate proteins, can be involved in various significant cellular processes and generate multiple biological effects. Currently, the best-characterized substrates of neddylation are the Cullin protein family, which is the core subunit of the Cullin-RING E3 ubiquitin ligase complex and controls many important biological processes by promoting ubiquitination and subsequent degradation of various key regulatory proteins. The normal or abnormal process of protein neddylation in the central nervous system can lead to a series of occurrences of normal functions and the development of diseases, providing an attractive, reasonable, and effective targeted therapeutic strategy. Therefore, this study reviews the phenomenon of neddylation in the central nervous system and summarizes the corresponding substrates. Finally, we provide a detailed description of neddylation involved in CNS diseases and treatment methods that may be used to regulate neddylation for the treatment of related diseases.
Neddylation是一种蛋白质翻译后修饰，它将类泛素蛋白NEDD8连接到底物蛋白上，可参与多种重要的细胞过程并产生多种生物学效应。目前，Neddylation最具特征的底物是Cullin蛋白家族，它是Cullin-RING E3泛素连接酶复合物的核心亚基，通过促进各种关键调节蛋白的泛素化及随后的降解来控制许多重要的生物学过程。中枢神经系统中蛋白质Neddylation的正常或异常过程可导致一系列正常功能的出现和疾病的发展，这为一种有吸引力、合理且有效的靶向治疗策略提供了依据。因此，本研究回顾了中枢神经系统中的Neddylation现象并总结了相应的底物。最后，我们详细描述了参与中枢神经系统疾病的Neddylation以及可能用于调节Neddylation以治疗相关疾病的治疗方法。
