Atkins Amanda, Koch Connor, James Sherin, Wodeyar Akhilesh, Sievert Matti, Goncalves Miguel, Jeyarajan Harishanker, Warram Jason M, Panuganti Bharat A
Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, U.S.A.
Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg (Erlangen-Nürnberg), Erlangen University Hospital, Erlangen, Germany.
Laryngoscope. 2025 May;135(5):1767-1770. doi: 10.1002/lary.31918. Epub 2024 Nov 20.
Confocal laser endomicroscopy (CLE) represents an emerging probe-based intraoperative optical imaging modality, contingent on differential fluoroscein uptake, equipped to improve intraoperative identification of subclinical mucosal disease. In the analysis herein, we describe improved sensitivity, compared to narrow band imaging and small-volume tissue biopsies, of CLE in the discrimination of occult disease based on cellular and subcellular morphology during endoscopic resection of early-staged larynx cancers. Laryngoscope, 135:1767-1770, 2025.